Olga G. Andreeva

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Intracerebroventricular (i.c.v.) treatment of mice with 6-hydroxydopamine (6-OHDA; 20–50μg per mouse), which depletes brain noradrenaline (NA) and DA, completely prevents or significantly diminishes the hypothermie effect of various classes of drugs: dopaminomimetics-apo-morphine (0.5–10 mg/kg), piribedil (40–100 mg/kg), bromocriptine (3 to 10mg/kg), CM(More)
The methodological approaches of isolation of preparations of FMDV structural polypeptides to analyse them by the electrophoresis and electro-focussing methods are presented. The value of isoelectric points of protein coat of FMDV structural polypeptides and corresponding them values of electric potential are determined. The similarity and differences of(More)
It was investigated the functional status of stem cell pool (CFUs) of bone marrow, spleen and peripheral blood in mice (CBA) in early (1-30 days) and late (180-360 days) period after acute intake of 90Sr (29.6 kBq/g). Cumulative dose in red bone marrow due to incorporated 90Sr was 0.98-87.7 Gy. The kinetics, proliferative and differentiative potential of(More)
Experiments demonstrated that the effect of water activity on the solvate complex of virions underlies the mechanism of thermal inactivation of the foot and mouth disease virus in suspension; changes in the structure of the complex impair the electrophysical balance of the RNA-protein relations and hence, destroy the virus. Heating of virus-containing(More)
Removal of moisture from concentrated virus suspensions in a sequential manner using ultrafiltration, active ventilation and vacuum dehydration of concentrated powders enables us to obtain preparations with a residual content of moisture less than 1%, while the structure and properties of FMD virus are retained. Mechanism of inactivation of FMD virus in(More)
Administration of 6-hydroxydopamine hydrobromide (20-50 mg) into the cerebral ventricles of mice products the depletion of noradrenaline and dopamine in the brain and counteracts the hypothermic effect of dopaminomimetic drugs of direct (apomorphine, piribedil, bromocryptin, CM29-712) and indirect (d, l-amphetamine, L-DOPA) type of action. Pretreatment of(More)
Porcine respiratory coronavirus is related genetically to porcine transmissible gastroenteritis virus with a large deletion in S protein. The respiratory virus is a mutated form that may be a consequence of the gastroenteritis virus’s evolution. Intensive passages of the virus in its natural host may enhance the appearance of mutations and therefore may(More)
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