Olena Davydova

Learn More
The effect of an anticoagulant and cytoprotector blood serine proteinase—activated protein C (APC)—on survival of cultured hippocampal and cortical neurons under conditions of glutamate-induced excitotoxicity has been studied. Low concentrations of APC (0.01–10 nM) did not cause neuron death, but in the narrow range of low concentrations APC twofold and(More)
We studied changes in the mRNA expression of protease receptors (PAR-1, PAR-2, PAR-3, and PAR-4) in primary neuroglial and glial cultures of rat cerebellum after a one hour deprivation of culture medium. Replacement of culture medium by saline induced an increase in the mRNA level of PAR-2 in cultures of both types, whereas the mRNA level of other receptors(More)
A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H-pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevant pyrazole scaffold. The scope and limitations of the methodology were studied.