Oleg V Dolgikh

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The cell structures involved into the apoptotic mechanism is an ideal object for the study of toxic effects produced by low-molecular-weight compounds on the immune system. Organic chlorine compounds and heavy metals were tested for their effects in the in vitro system. The experiments show that organic chlorine compounds inhibit apoptotic cell death. An(More)
The article presents results of the evaluation the changes in the relationships between immune and endocrine systems in reproductive-age women, working under exposure to chemical factors from activated carbon production. A significant increase of some chemical elements and compounds was found in blood that was associated with changes in the endocrine and(More)
Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders. Individual risk of endocrine disorders (ICD: E67.8 excessive nutrition and E66.0(More)
Medical examination covered female workers engaged into chemical production of technical rubber goods, under combined exposure to chemicals (nitrogen oxides, carbon oxide) and noise exceeding MAC by 3.7-27.5%. Findings are increased phagocytary activity, lower level of serum IgM and IgG, suppressed expression of CD25 and CD95 T-cell receptors, and slower(More)
There was performed a comparative analysis of immunogenetic indices in non-ferrous metallurgy employees under the exposure to different combinations of harmful occupational factors. The combined effect of chlorine and vanadium fumes, noise, overall vibration appeared to be associated with the gene polymorphism of cytokine regulation--VEGF and TNF (p <(More)
Workers exposed to aromatic hydrocarbons appeared to have prevalence of heterozygous variants of CYP1A1 gene (9893 A/G) and tumor necrosis factor gene reliably higher vs. the reference group 2.5 and 3.3 times respectively, and level of anti-benzene antibodies (IgG) increased vs. the reference group. The data presented demonstrate negative immunogenetic(More)
The authors evaluated influence of phenol, o-cresol, m-cresol and p-cresol on cellular immunity in apparatus operators engaged into chemical production. Detection covered significant membrane and intracellular markers characterizing peculiarities of cellular immune reactions in contamination with phenols (CD4+ deficit, hyperproduction of FoxP3 and CD25+).
Comparative analysis covered immune genetic parameters in nonferrous metallurgy workers. The authors demonstrated differences in immune genetic profile between male and female workers, under exposure to combination of occupational hazards: noise and dust. Analysis of gene polymorphism revealed predominant disorders in the female workers, concerning(More)
The study of the effects of motor transport exhausts in the city of Perm on human lead levels has indicated that the employees of the State Motor-Vehicle Inspectorate whose working place is a highway have increased lead concentrations which in the blood are 3 times greater than normal values and which in the urine are 1.3 times higher. The content of lead(More)