Oleg N Minushkin

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OBJECTIVES:Chronic constipation is a common, persistent disorder with limited effective treatment options. This study investigated the efficacy, safety, and tolerability of tegaserod in the treatment of chronic constipation.METHODS:After a 2-wk baseline period, patients were randomized to double-blind treatment of 12 wk with tegaserod (2 or 6 mg b.i.d.) or(More)
Sixty patients with chronic hepatitis of various etiology at the stage of hepatic cirrhosis with hepatic encephalopathy syndrome (HES), thirty patients with cerebral atherosclerosis with dyscirculatory encephalopathy (DE) and 60 healthy controls have been examined in the study of basic diagnostic criteria of encephalopathies by short-chain fatty acids(More)
AIM Elucidation of the significance of various factors in prognosis of duodenal ulcer (DU) severity. MATERIALS AND METHODS The observational study entered 18 new cases of DU and 13 healthy controls. All the patients were followed up for 7 years with annual esophagogastroduodenoscopy. RESULTS 10 patients (group 1) had annual exacerbations of DU, 8(More)
Examination and long-term follow-up covered 95 patients with duodenal ulcer (DU). Mean age of the patients was 32 +/- 1.67 years. The patients were divided into two groups: with rare DU recurrences (n = 36) and with frequent recurrences (n = 59). Diagnostic criteria for development of rarely recurrent DU were the following: blood group A(II), exacerbations(More)