Oleg Museyko

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Despite an increasing use of high-resolution peripheral quantitative computed tomography (HR-pQCT) to evaluate bone morphology in vivo, there are reservations about its applicability in patients with osteoporosis and antiresorptive therapy. This study shows that HR-pQCT provides acceptable in vivo accuracy for bone volume fraction (BV/TV) in patients with(More)
Quantitative computer tomography (QCT)-based finite element (FE) models of vertebral body provide better prediction of vertebral strength than dual energy X-ray absorptiometry. However, most models were validated against compression of vertebral bodies with endplates embedded in polymethylmethalcrylate (PMMA). Yet, loading being as important as bone(More)
The quantification of changes in the trabecular bone structure induced by musculoskeletal diseases like osteoarthritis, osteoporosis, rheumatoid arthritis, and others by means of a texture analysis is a valuable tool which is expected to improve the diagnosis and monitoring of a disease. The reaction of texture parameters on different alterations in the(More)
OBJECTIVE To monitor size and shape changes of bone erosions and changes in BMD in the vicinity of the erosion and in the periarticular trabecular compartment of patients with RA using high-resolution peripheral quantitative CT (HR-pQCT) imaging and to compare an automated three-dimensional (3D) image processing technique with manual measurements of erosion(More)
OBJECTIVE Bone marrow lesions (BMLs) in the knee are associated with pain and compartment-specific joint space narrowing. However, the correlation of BMLs with bone mineral density (BMD) has rarely been investigated. The aim of the present study was to examine whether BMD in BMLs is altered compared to the surrounding bone. DESIGN Thirty-four BMLs(More)
BACKGROUND Angiogenesis is an important pathophysiological process of chronic inflammation, especially in inflammatory arthritis. Quantitative measurement of changes in vascularization may improve the diagnosis and monitoring of arthritis. The aim of this work is the development of a 3D imaging and analysis framework for quantification of vascularization in(More)
We have developed a new integrated approach for quantitative computed tomography of the knee in order to quantify bone mineral density (BMD) and subchondral bone structure. The present framework consists of image acquisition and reconstruction, 3-D segmentation, determination of anatomic coordinate systems, and reproducible positioning of analysis volumes(More)
Cadaver and phantom measurements and simulations confirmed that radiation exposure in 3D QCT of the spine can be reduced if 80 kV instead of 120 kV protocols are used; 120 mAs and slice thicknesses of 1–1.3 mm should be usable but obese patient will require higher milliampere-second settings. To develop a low-radiation exposure CT acquisition protocol for(More)
For quantitative computed tomography (QCT), most relevant variables to discriminate hip fractures were determined. A multivariate analysis showed that trabecular bone mineral density (BMD) of the trochanter with “cortical” thickness of the neck provided better fracture discrimination than total hip integral BMD. A slice-by-slice analysis of the neck or the(More)
Articular cartilage and subchondral bone are the key tissues in osteoarthritis (OA). The role of the cancellous bone increasingly attracts attention in OA research. Because of its fast adaptation to changes in the loading distribution across joints, its quantification is expected to improve the diagnosis and monitoring of OA. In this study, we simulated OA(More)