Oleg Kolosov

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According to the "amyloid cascade" hypothesis of Alzheimer disease, the formation of Aβ fibrils and senile plaques in the brain initiates a cascade of events leading to the formation of neurofibrillary tangles, neurodegeneration, and the symptom of dementia. Recently, however, emphasis has shifted away from amyloid fibrils as the predominant toxic form of(More)
The structure of nanometer-sized strained Ge islands epitaxially grown on a Si substrate was studied using ultrasonic force microscopy (UFM), which combines the sensitivity to elastic structure of acoustic microscopy with the nanoscale spatial resolution of atomic force microscopy. UFM not only images the local surface elasticity variations between the Ge(More)
While mechanical and frictional properties of graphene in air have been extensively studied, graphene's nanomechanical behavior in liquids, vital for its operation in rechargeable batteries, supercapacitors, and sensors, is still largely unexplored. In this paper, we investigate the nanomechanics of normal (adhesive and elastic) and tangential (friction)(More)
Two-dimensional (2D) compounds provide unique building blocks for novel layered devices and hybrid photonic structures. However, large surface-to-volume ratio in thin films enhances the significance of surface interactions and charging effects requiring new understanding. Here we use micro-photoluminescence (PL) and ultrasonic force microscopy to explore(More)
Previously, we have developed a retro-inverso peptide inhibitor (RI-OR2, rGffvlkGr) that blocks the in vitro formation and toxicity of the Aβ oligomers which are thought to be a cause of neurodegeneration and memory loss in Alzheimer's disease. We have now attached a retro-inverted version of the HIV protein transduction domain 'TAT' to RI-OR2 to target(More)
The analysis of the formation of ultra-thin organic films is a very important issue. In fact, it is known that the properties of organic light emitting diodes and field effect transistors are strongly affected by the early growth stages. For instance, in the case of sexithiophene, the presence of domains made of molecules with the backbone parallel to the(More)
We report direct imaging of nanoscale thermal transport in single and few-layer graphene with approximately 50 nm lateral resolution using high vacuum scanning thermal microscopy. We observed increased heat transport in suspended graphene where heat is conducted by ballistic phonons, compared to adjacent areas of supported graphene, and observed decreasing(More)
Nanopatterning techniques have applications across a wide range of experimental sciences, from controlling cell growth and function [ 1 ] to improving the effi ciency of thin fi lm solar cells. [ 2 ] Approaches developed by the microelectronics industry such as photon-, ionand electron-beam lithography are highly refi ned, producing features with dimensions(More)
Aggregation of amyloid-β peptide (Aβ) is a key event in the pathogenesis of Alzheimer's disease (AD). We investigated the effects of nanoliposomes decorated with the retro-inverso peptide RI-OR2-TAT (Ac-rGffvlkGrrrrqrrkkrGy-NH2) on the aggregation and toxicity of Aβ. Remarkably low concentrations of these peptide inhibitor nanoparticles (PINPs) were(More)