Oleg Kiselev

Markus Wolschek3
Andrej Egorov3
Thomas Muster3
Julia Romanova3
Boris Ferko2
3Markus Wolschek
3Andrej Egorov
3Thomas Muster
3Julia Romanova
2Boris Ferko
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  • Julia Romanova, Brigitte M. Krenn, Markus Wolschek, Boris Ferko, Ekaterina Romanovskaja-Romanko, Alexander Morokutti +14 others
  • 2009
BACKGROUND We developed a novel intranasal influenza vaccine approach that is based on the construction of replication-deficient vaccine viruses that lack the entire NS1 gene (DeltaNS1 virus). We previously showed that these viruses undergo abortive replication in the respiratory tract of animals. The local release of type I interferons and other cytokines(More)
  • Franco Venanzi, Victor Shifrin, Michael Y. Sherman, Vladimir Gabai, Oleg Kiselev, Andrey Komissarov +15 others
  • 2013
Autophagy plays an important role in neoplastic transformation of cells and in resistance of cancer cells to radio- and chemotherapy. p62 (SQSTM1) is a key component of autophagic machinery which is also involved in signal transduction. Although recent empirical observations demonstrated that p62 is overexpressed in variety of human tumors, a mechanism of(More)
  • Brigitte M. Krenn, Andrej Egorov, Ekaterina Romanovskaya-Romanko, Markus Wolschek, Sabine Nakowitsch, Tanja Ruthsatz +17 others
  • 2011
BACKGROUND H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAIV) was shown to be more susceptible to acidic pH treatment than that of human or low pathogenic avian(More)
  • Christian Kittel, Nina Wressnigg, Anna Polina Shurygina, Markus Wolschek, Marina Stukova, Ekatherina Romanovskaya-Romanko +4 others
  • 2015
The existence of multiple antigenically distinct types and subtypes of influenza viruses allows the construction of a multivalent vector system for the mucosal delivery of foreign sequences. Influenza A viruses have been exploited successfully for the expression of extraneous antigens as well as immunostimulatory molecules. In this study, we describe the(More)
BACKGROUND Recombinant hemagglutinin (rHA) and neurominidase (rNA) developed in our investigation are amino acid sequence consensus variants of H1N1 2009 subtype influenza virus strain, also including immunogenic epitopes typical for other influenza virus subtypes (H3N1 and H5N1). Substitutions were made: typical for Russian virus isolates (in HA - S220T,(More)
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