Ole Norling Mathiassen

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OBJECTIVES The goal of this study was to assess the real-world clinical utility of fractional flow reserve (FFR) derived from coronary computed tomography angiography (FFRCT) for decision-making in patients with stable coronary artery disease (CAD). BACKGROUND FFRCT has shown promising results in identifying lesion-specific ischemia. The real-world(More)
OBJECTIVE Structural abnormality of resistance arteries is a characteristic pathophysiological phenomenon in essential hypertension and can be assessed in vitro as an increase in the media: lumen ratio (M: L) of isolated small arteries. We have investigated whether M: L is a risk predictor in uncomplicated essential hypertensive patients. Recently, high M:(More)
OBJECTIVE Structural changes of small resistance arteries occur early in the disease process of essential hypertension and predict cardiovascular events in previously untreated patients. We investigated whether on-treatment small artery structure also identifies patients at elevated risk despite normalization of blood pressure (BP). METHODS We conducted a(More)
BACKGROUND There are limited data on the incidence, clinical implications, and predisposing factors of transcatheter heart valve (THV) thrombosis following transcatheter aortic valve replacement (TAVR). OBJECTIVES The authors assessed the incidence, potential predictors, and clinical implications of THV thrombosis as determined by contrast-enhanced(More)
BACKGROUND Renal denervation (RDN), treating resistant hypertension, has, in open trial design, been shown to lower blood pressure (BP) dramatically, but this was primarily with respect to office BP. METHOD We conducted a SHAM-controlled, double-blind, randomized, single-center trial to establish efficacy data based on 24-h ambulatory BP measurements(More)
BACKGROUND Essential hypertension is characterized by small artery remodeling and increased systemic vascular resistance (SVR). We hypothesized that changes in SVR index (SVRI) were associated with measures of small artery structure as reflected by minimum coronary and forearm vascular resistance (C-Rmin and F-Rmin, respectively). Also, we investigated how(More)
Efficient cardiopulmonary resuscitation (CPR) contributes to improved outcome after cardiac arrest. New mechanical devices improve cardiac output. We present a case-report with a male patient who was admitted after 55 minutes of out-of-hospital CPR which was followed by 45 minutes of in-hospital CPR with a mechanical device (LUCAS). Cardiac arrest was due(More)
AIM High peripheral resistance and structural alteration in resistance arteries are central phenomena in essential hypertension and have been widely examined by forearm venous occlusion plethysmography; at rest for studying vascular tone, and during reactive hyperaemia for studying vascular structure. This work concerns the influence of venous pressure on(More)
OBJECTIVE Correction of the abnormal structure of resistance arteries in essential hypertension may be an important treatment goal in addition to blood pressure (BP) reduction. We investigated how this may be achieved in a prospective clinical study. METHODS Plethysmography was used to measure forearm resting vascular resistance (Rrest) and minimum(More)
BACKGROUND Increased microvascular resistance and small artery remodelling are key abnormalities in the pathophysiology of essential hypertension. We investigated the relation between the impairment of coronary and forearm minimum vascular resistances (C-Rmin and F-Rmin) and the degree of hypertension. METHOD Seventy-five never-treated essential(More)