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Locomotor circuits in the mammalian spinal cord.

• Ole Kiehn
• Annual review of neuroscience
• 2006

Intrinsic spinal networks, known as central pattern generators (CPGs), control the timing and pattern of the muscle activity underlying locomotion in mammals. This review discusses new advances in… (More)

Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study.

• Ole Kjaerulff, Ole Kiehn
• The Journal of neuroscience : the official…
• 1996

The isolated spinal cord of the newborn rat contains networks that are able to create a patterned motor output resembling normal locomotor movements. In this study, we sought to localize the regions… (More)

Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan.

• Jørn Hounsgaard, Hans Hultborn, Bo Jespersen, Ole Kiehn
• The Journal of physiology
• 1988

1. In the preceding paper (Crone, Hultborn, Kiehn, Mazieres & Wigström, 1988) it was shown that a short-lasting synaptic excitation ('on' stimulus) of extensor motoneurones (primarily triceps surae)… (More)

Compartmental model of vertebrate motoneurons for Ca2+-dependent spiking and plateau potentials under pharmacological treatment.

• Victoria Booth, John Rinzel, Ole Kiehn
• Journal of neurophysiology
• 1997

In contrast to the limited response properties observed under normal experimental conditions, spinal motoneurons generate complex firing patterns, such as Ca2+-dependent regenerative spiking and… (More)

Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.

• Klas Kullander, Simon J B Butt, +5 authors Ole Kiehn
• Science
• 2003

Local circuits in the spinal cord that generate locomotion are termed central pattern generators (CPGs). These provide coordinated bilateral control over the normal limb alternation that underlies… (More)

V1 spinal neurons regulate the speed of vertebrate locomotor outputs

• Simon Gosgnach, Guillermo M Lanuza, +7 authors Martyn Goulding
• Nature
• 2006

The neuronal networks that generate vertebrate movements such as walking and swimming are embedded in the spinal cord. These networks, which are referred to as central pattern generators (CPGs), are… (More)

Prolonged firing in motor units: evidence of plateau potentials in human motoneurons?

• Ole Kiehn, T Eken
• Journal of neurophysiology
• 1997

Serotonin (5-HT) and norepinephrine-dependent plateau potentials are found in spinal motoneurons in reduced turtle and cat preparations. Triggering the plateau potential by short-lasting synaptic… (More)

Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential.

• Jørn Hounsgaard, Ole Kiehn
• The Journal of physiology
• 1989

1. The effect of serotonin on the firing properties of motoneurones was studied in transverse sections of the adult turtle spinal cord in vitro with intracellular recording techniques. 2. In normal… (More)

Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat.

• Ole Kiehn, Ole Kjaerulff
• Journal of neurophysiology
• 1996

1. Rhythmic activity was induced with either serotonin (5-HT; 10-100 microM) or dopamine (0.1-1.0 mM), in the in vitro spinal cord preparation of neonatal rats, with one intact hindlimb attached.… (More)

Genetic Ablation of V2a Ipsilateral Interneurons Disrupts Left-Right Locomotor Coordination in Mammalian Spinal Cord

• Steven A. Crone, Katharina A. Quinlan, +8 authors K. Naraayana Sharma
• Neuron
• 2008

The initiation and coordination of activity in limb muscles are the main functions of neural circuits that control locomotion. Commissural neurons connect locomotor circuits on the two sides of the… (More)

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