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No kinetic data are available to indicate the influence of a rough track surface and the resultant loss of footing on the components of hoof vertical forces. The aim of the present study was to evaluate the influence of rough track surfaces on the components of hoof vertical forces. Seven clinically sound 2-year-old Thoroughbred horses had instrumented(More)
We recorded the electromyographic (EMG) activity of 7 skeletal muscles in the forequarters and 1 in the hindquarters of 6 Thoroughbred horses during overground walking, swimming in a circular pool, and walking and trotting in a water treadmill. Bipolar fine wire electrodes were inserted into the muscles and the EMG signals were recorded using a telemetric(More)
OBJECTIVE To develop an instrument that could be sandwiched between the hoof and shoe of horses and that would reliably measure vertical ground reaction forces and three-dimensional acceleration at the walk, trot, and canter. ANIMALS 5 clinically sound Thoroughbreds. PROCEDURES The recording instrument (weight, 350 g) consisted of 2 metal plates, 2(More)
PURPOSE The purpose of this study was to define membrane controlling factors responsible for drug release from a controlled-porosity osmotic pump tablet (OPT) that utilizes a sulfobutyl ether-beta-cyclodextrin, (SBE)(7m)-beta-CD, as both a solubilizing and osmotic agent. METHOD The OPT was spray coated with cellulose acetate solutions varying the amount(More)
Electromyographic (EMG) activity of 4 muscles of the cubital joint and the strain of forelimb hooves were recorded telemetrically in 4 Thoroughbreds (with and without a rider) standing, walking, trotting, and cantering. Bipolar fine wire electrodes were inserted into the muscles, and strain gauges were attached to the hoof wall. Motion pictures (16 mm),(More)
The mechanism by which cells take up retinol from retinol-binding protein (RBP) and the role of the RBP-transthyretin (TTR) complex remain unclear. Here we report on retinol uptake through the RBP-TTR complex by primary cultured rat hepatocytes (parenchymal cells, PC) and nonparenchymal cells (NPC) following incubation with [3H]retinol-RBP or the(More)
PURPOSE The purpose of this study was to develop a controlled-porosity osmotic pump tablet (OPT) which exhibits pH-independent release profiles for a basic drug using a sulfobutyl ether-beta-cyclodextrin, (SBE)7m-beta-CD, which acts as both a solubilizer and as an osmotic agent. METHODS Chlorpromazine free base (CLP) was chosen as a model drug for this(More)
  • O Aoki
  • 1999
Most of the principles of farriery have been derived from practical experience and traditional skills of individual farriers. To date, there has been little done in the way of good science and few publications have appeared to advance the discipline. Therefore, opinions or policies on horse shoeing vary greatly between farriers and members of the veterinary(More)
as analyte concentrations increased, within-and between-day imprecision decreased. The CVs of these samples, when assay dilution was accounted for, were consistent with the low (ng/L) LOQ estimated for each SMIA. Highly sensitive and precise SMIAs with excellent recoveries for several other analytes were also developed (Table 1 and see Fig. S1C in the(More)
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