Oksana G. Shevchenko

Learn More
A series of water-soluble conjugates has been synthesized from polyethylene glycols of various lengths and 4-bromomethyl-2,6-diisobornylphenol. The membrane protective and antioxidant activities of the synthesized products were evaluated on the model of the H2O2-induced hemolysis of erythrocytes. It was shown that the studied conjugates have a significant(More)
Most age-related diseases and aging itself are associated with chronic inflammation. Thus pharmacological inhibition of inflammatory processes may be effective antiaging strategy. In this study we demonstrated that treatment of Drosophila melanogaster with 10 non-steroidal anti-inflammatory drugs (NSAIDs: CAY10404, aspirin, APHS, SC-560, NS-398, SC-58125,(More)
In the present work, we investigated the dark and photoinduced cytotoxic activity of the new chlorophyll-a derivatives which contain the substituents of oligoethylene glycol on the periphery of their macrocycles. These compounds were tested using human cell lines to estimate their potential as photosensitizers for photodynamic therapy of cancer. It was(More)
Neomenthane and isobornane thiol-derived sulfanyl imines were prepared in yields of up to 85%. On the basis of the capacity of the sulfanyl imines obtained to inhibit the H2H2- and AAPH-induced erythrocyte hemolysis and impede the accumulation of secondary products of lipid peroxidation and hemoglobin oxidation, they were shown to display membrane(More)
Two diastereomers of methylpheophorbide a 13(2)-N-n-octyl-N-(2-hydroxy-3-isobornyl-5-methylbenzyl)amide were obtained from (+)- and (−)-enantiomers of 2-isobornyl-4-methylphenol. The evaluation of the membrane protective and antioxidant activity of the individual diastereomers on the model of H2O2-induced hemolysis of blood erythrocytes showed that the(More)
The membrane protective and membrane active properties and the antioxidative activity of new semisynthetic antioxidants—isobornylphenols were studied. The presence of oxidant and cytotoxic properties of the compounds were evaluated considering the degree of hemolysis of erythrocytes, either spontaneous or induced by hydrogen peroxide. All the studied(More)
A series of conjugates has been synthesized by the reaction of methylpheophorbide a with ortho-alkylaminomethyl derivatives of 2-isobornyl-4-methylphenol; the terpenophenol fragment in the conjugates is attached to the methylpheophorbide a macrocycle by an amide bond formed upon the amidation of the 13(2)-ester group. A scanning electron microscopy study of(More)
  • 1