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BACKGROUND The present study examined the integrity of the P300 component of the event-related potential (ERP) in patients at high imminent risk for schizophrenia in relation to healthy comparison subjects and patients in the recent-onset and chronic stages of schizophrenia. METHODS The P300 was recorded by using an auditory oddball task in 10 patients(More)
The P3 event-related potential (ERP) component was recorded from 7- to 18-year-old children of alcoholics (COAs, n = 50) and age- and sex-matched control children (n = 50) using a visual oddball paradigm, involving nontarget (76%), target (12%), and novel (12%) stimuli. Topographic maps of P3 and associated scalp current density were obtained to supplement(More)
Our understanding of developmental changes in attentional selection in the growing child has been advanced substantially by the results of (a relatively small number of) studies undertaken from a psychophysiological perspective. The basic outcome of these studies is that, in attentional filtering as well as selective set (the two basic paradigms in(More)
The electroencephalogram (EEG) recorded from the human scalp is widely used to study cognitive and brain functions in schizophrenia. Current research efforts are primarily devoted to the assessment of event-related potentials (ERPs) and event-related oscillations (EROs), extracted from the ongoing EEG, in patients with schizophrenia and in clinically(More)
BACKGROUND In this study, we assessed the integrity of several components of the event-related potential (ERP) associated with different levels of visual and auditory processing in patients with schizophrenia. The objective was to clarify whether high-level attention-dependent cognitive deficits, as indexed by the P3 component, in patients with(More)
BACKGROUND Research has indicated a close relationship between the P3 event-related potential and the dopamine D2 receptor A1 allele in individuals at high risk for alcoholism. Other research has suggested an association between the dopamine D2 receptor A1 allele and sensation-seeking. In this study, we further examined the relationships between the P3, the(More)
Recent data from the Amsterdam Study of Children of Alcoholics add to the evidence for considering the P300 or P3 component of the event-related potential (ERP) as a potential vulnerability marker of alcoholism. In this study, multi-channel ERPs were recorded from 7- to 18-year-old children of alcoholics (COAs) and age- and sex-matched low-risk controls(More)
This review considers several neurochemical characteristics or trait markers that may be related to a genetic vulnerability to alcoholism. These potential neurochemical markers of alcoholism vulnerability include indices of activity of five neurotransmitter systems, namely gamma-aminobutyric acid, serotonin, dopamine, noradrenaline and beta-endorphin. This(More)
In order to gain insight into the functional and macroanatomical loci of visual selective processing deficits that may be basic to attention-deficit hyperactivity disorder (ADHD), the present study examined multi-channel event-related potentials (ERPs) recorded from 7- to 11-year-old boys clinically diagnosed as having ADHD (n=24) and age-matched healthy(More)
The mismatch negativity (MMN) event-related potential (ERP) component is an automatic, attention-independent brain response to auditory stimulus change, which has been reported to be smaller in alcoholics relative to nonalcoholic controls. To determine whether MMN decrements might be a trait marker of alcoholism that is also present in nonalcoholic(More)