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STUDY OBJECTIVE Laboratory evidence indicates that progesterone has potent neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential benefit of administering progesterone to patients with acute traumatic brain injury. METHODS This phase II, randomized, double-blind, placebo-controlled trial was conducted at an urban(More)
The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this(More)
CONTEXT Hypothermia is utilized in the management of severe traumatic brain injury despite the lack of unequivocal evidence supporting its use. Because of its widespread use, the effects of hypothermia are a concern. OBJECTIVE To determine the effectiveness of hypothermia in the management of severe brain injury. DATA SOURCES Two investigators working(More)
OBJECT We evaluated management and outcome of traumatic brain injury (TBI) in a developed country (US) and a developing country (Jamaica). METHODS Data were collected prospectively at Grady Memorial Hospital (GMH) in the US and at University Hospital of the West Indies (UHWI) and Kingston Public Hospital (KPH) in Jamaica between September 1, 2003, and(More)