Oberarzt Dr. W. Neuhaus

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The surface of alpha beta T cells express a heterodimeric T cell receptor (TCR) composed of an alpha- and a beta-chain. In TCR-alpha gene disruption mutant mice, T cells can be identified which surface-express the TCR-beta chain in the absence of the TCR-alpha chain. Characteristically, intestinal intraepithelial lymphocytes (i-IELs) constitutively express(More)
Naeh Entfernung der GMlenblase wegell eines Steinleidens treten h~Lufig Besehwerdell auf, die hinsiehtlieh S~hmerzhaftigkeit und der Beeintraeht igung des Allgemeh~befindens den StSrungen nicht naehstehen, wie sie vor der Operat ion bes tanden haben. Oft ist die Ursache ein zuriickgelassener kleiner Stein, der auch mi t Flilfe yon GMlenlSffeln und Sonden(More)
Numerous microbial pathogens, including Listeria monocytogenes, enter the host through the intestine. Although relatively little is known about the biological functions of intestinal intraepithelial lymphocytes (i-IEL), they are generally considered a first line of defense against intestinal infections. In the mouse, the vast majority of i-IEL express the(More)
Murine intestinal intraepithelial lymphocytes (i-IEL) comprise thymus-dependent cells such as T cell receptor (TcR) alpha/beta CD8 alpha/beta+ i-IEL, as well as thymus-independent ones such as TcR alpha/beta CD8 alpha/alpha+ and TcR gamma/delta CD8 alpha/alpha+ i-IEL. Whilst the development of the CD8 alpha/beta expressing i-IEL is strictly contingent on(More)
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