Oana Popa

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Single ion channel currents can be analysed by hidden or aggregated Markov models. A classical result from Fredkin et al. (Proceedings of the Berkeley conference in honor of Jerzy Neyman and Jack Kiefer, vol I, pp 269-289, 1985) states that the maximum number of identifiable parameters is bounded by 2n(o)n(c), where n(o) and n(c) denote the number of open(More)
—In the medical domain, the continuous stream of scientific research contains contradictory results supported by arguments and counter-arguments. As medical expertise occurs at different levels, part of the human agents have difficulties to face the huge amount of studies, but also to understand the reasons and pieces of evidences claimed by the proponents(More)
Voltage-gated Na(+) channels play a fundamental role in the excitability of nerve and muscle cells. Defects in fast Na(+) channel inactivation can cause hereditary muscle diseases with hyper- or hypoexcitability of the sarcolemma. To explore the kinetics and gating mechanisms of noninactivating muscle Na(+) channels on a molecular level, we analyzed single(More)
Voltage-gated Na 1 channels play a fundamental role in the excitability of nerve and muscle cells. Defects in fast Na 1 channel inactivation can cause hereditary muscle diseases with hyper-or hypoexcitability of the sarcolemma. To explore the kinetics and gating mechanisms of noninactivating muscle Na 1 channels on a molecular level, we analyzed single(More)
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