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DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth
- Saburo Yamamoto, Toshiko Yamamoto, T. Tokunaga
- Biology, ChemistryMicrobiology and immunology
- 1 September 1992
The nucleic acid fraction from cells of 6 species of bacterium and 2 kinds of vertebrate, calf and salmon, was extracted and purified and it was shown that the factor to activate macrophages was interferon (IFN)‐gamma and that to inhibit viral growth was IFN‐alpha/beta.
Synthetic Oligonucleotides with Particular Base Sequences from the cDNA Encoding Proteins of Mycobacterium bovis BCG Induce Interferons and Activate Natural Killer Cells
It is suggested that certain palindrome sequences, like GACGTC, GGCGCC and TGCGCA, are essential for 30‐mer oligonucleotides, like BCG‐A4a, to induce IFNs.
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.
- T. Tokunaga, H. Yamamoto, T. Sudo
- Biology, ChemistryJournal of the National Cancer Institute
- 1 April 1984
A fraction extracted from Mycobacterium bovis strain BCG, which was composed of 70% DNA, 28.0% RNA, 1.3% protein, 0.20% glucose, and 0.1% lipid, was found to possess strong antitumor activity, suggesting that the DNA from BCG possessed strong antitUMor activity under certain conditions.
Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.
- S. Yamamoto, T. Yamamoto, T. Kataoka, E. Kuramoto, O. Yano, T. Tokunaga
- Biology, ChemistryJournal of immunology
- 15 June 1992
The results strongly suggest that the presence of the unique palindromic sequences, such as GACGTC, AGCGCT, and AACGTT, but not ACCGGT, is essential for the immunostimulatory activity of oligonucleotides.
Purification of KBF1, a common factor binding to both H‐2 and beta 2‐microglobulin enhancers.
- O. Yano, J. Kanellopoulos, M. Kieran, O. Le Bail, A. Israël, P. Kourilsky
- BiologyThe EMBO journal
- 1 November 1987
Gel retardation and footprint analysis have shown that purified KBF1 has a binding activity specific for both H‐2 and beta 2‐microglobulin enhancer sequences, suggesting that the expression of both H•2 and Beta 2‐ microglobulins genes utilizes a common regulatory mechanism.
Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors.
- S. Shimada, O. Yano, T. Tokunaga
- Biology, MedicineJournal of the National Cancer Institute
- 1 March 1985
MY-1 was equally effective in mice with or without presensitization with BCG, whereas BCG was much more effective in BCG-sensitized mice, suggesting that a delayed-type hypersensitivity reaction elicited by BCG protein is not required for the antitumor activity of MY-1.
A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes.
- A. Israël, A. Kimura, P. Kourilsky
- BiologyProceedings of the National Academy of Sciences…
- 1 May 1987
Using gel retardation and in vitro "footprinting", we have analyzed the interactions between nuclear proteins derived from various mouse cells and the enhancer and interferon response sequences of…
Oligonucleotide Sequences Required for Natural Killer Cell Activation
The results indicated that the activity depended critically on the presence of particular palindromic sequences including the 5 ‐CG‐3 motif(s), and the size and the number of Palindromes showed the strongest activity among the oligonucleotides tested.
Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer.
- T. Suzuki, N. Fukazawa, K. San-nohe, W. Sato, O. Yano, T. Tsuruo
- Chemistry, BiologyJournal of medicinal chemistry
- 20 June 1997
The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of interacting with hydrogen bond donors of P-170 glycoprotein (P-gp) via pi-hydrogen-pi interactions.
Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells.
The absence of KBF1 activity in undifferentiated EC cells is at least in part responsible for the lack of expression of H-2 class I and beta-2-microglobulin genes in these cells and suggests that KBF 1 activity is regulated during differentiation.