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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
Mitochondria play an important role in energy production, Ca2+ homeostasis and cell death. In recent years, the role of the mitochondria in apoptotic and necrotic cell death has attracted much… Expand
A Quantitative Analysis of mRNA Expression of α1 and β-adrenoceptor Subtypes and Their Functional Roles in Human Normal and Obstructed Bladders
ABSTRACTPurpose: We compared the expression level of α1-adrenoceptor (AR) subtype mRNA to that of β-AR subtype mRNA in control and obstructed human bladders, and examined whether α1-AR mediated… Expand
The role of autophagy in the heart
- K. Nishida, S. Kyoi, O. Yamaguchi, J. Sadoshima, K. Otsu
- Biology, Medicine
- Cell Death and Differentiation
Autophagy has evolved as a conserving process that uses bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. In the heart, autophagy is important for… Expand
Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study.
- M. Asakura, Y. Ueda, +4 authors K. Kodama
- Journal of the American College of Cardiology
- 1 April 2001
OBJECTIVES To test our hypothesis that the development of vulnerable plaques is not limited to the culprit lesions, but is a pan-coronary process, we directly observed all three major coronary… Expand
Clinical proof of concept study (blossom) shows novel beta 3 adrenoceptor agonist YM178 is effective and well tolerated in the treatment of symptoms of overactive bladder
Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle.
PURPOSE To investigate the presence of the beta3-adrenoceptor (beta3-AR) in human and rat detrusor muscle and the usefulness of beta3-AR agonists as drugs for the treatment of urinary frequency. … Expand
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
- O. Yamaguchi, T. Watanabe, +18 authors K. Otsu
- The Journal of clinical investigation
- 1 October 2004
The Raf/MEK/extracellular signal-regulated kinase (ERK) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and apoptosis and is implicated as an important… Expand
Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.
- M. Ueno, J. Suzuki, +8 authors I. Miyamori
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 1 June 2008
Intracellular lipid accumulation (steatosis) and resultant lipotoxicity are key features of diabetic cardiomyopathy. Since cardiac hormone-sensitive lipase (HSL) is activated in diabetic mice, we… Expand
Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.
- N. Kushida, Y. Kabuyama, O. Yamaguchi, Y. Homma
- Medicine, Biology
- American journal of physiology. Cell physiology
- 1 October 2001
Mechanical stretch has been implicated in phenotypic changes as an adaptive response to stretch stress physically loaded in bladder smooth muscle cells (BSMCs). To investigate stretch-induced… Expand
Urodynamic studies on hemiplegic patients after cerebrovascular accident.
Thirty-nine hemiplegic patients were evaluated by complete urodynamic study after cerebrovascular accidents. Computerized tomography was performed to identify localization of the brain lesion. The… Expand