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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
Mitochondria play an important role in energy production, Ca2+ homeostasis and cell death. In recent years, the role of the mitochondria in apoptotic and necrotic cell death has attracted muchExpand
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A Quantitative Analysis of mRNA Expression of α1 and β-adrenoceptor Subtypes and Their Functional Roles in Human Normal and Obstructed Bladders
ABSTRACTPurpose: We compared the expression level of α1-adrenoceptor (AR) subtype mRNA to that of β-AR subtype mRNA in control and obstructed human bladders, and examined whether α1-AR mediatedExpand
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  • Open Access
The role of autophagy in the heart
Autophagy has evolved as a conserving process that uses bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. In the heart, autophagy is important forExpand
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Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study.
OBJECTIVES To test our hypothesis that the development of vulnerable plaques is not limited to the culprit lesions, but is a pan-coronary process, we directly observed all three major coronaryExpand
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Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle.
PURPOSE To investigate the presence of the beta3-adrenoceptor (beta3-AR) in human and rat detrusor muscle and the usefulness of beta3-AR agonists as drugs for the treatment of urinary frequency. Expand
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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
The Raf/MEK/extracellular signal-regulated kinase (ERK) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and apoptosis and is implicated as an importantExpand
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Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.
Intracellular lipid accumulation (steatosis) and resultant lipotoxicity are key features of diabetic cardiomyopathy. Since cardiac hormone-sensitive lipase (HSL) is activated in diabetic mice, weExpand
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Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.
Mechanical stretch has been implicated in phenotypic changes as an adaptive response to stretch stress physically loaded in bladder smooth muscle cells (BSMCs). To investigate stretch-inducedExpand
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Urodynamic studies on hemiplegic patients after cerebrovascular accident.
Thirty-nine hemiplegic patients were evaluated by complete urodynamic study after cerebrovascular accidents. Computerized tomography was performed to identify localization of the brain lesion. TheExpand
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