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Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway
This paper investigates the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and simulation. Expand
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Why model?
Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example,Expand
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Fuzzy Clustering of Short Time-Series and Unevenly Distributed Sampling Points
This paper proposes a new algorithm in the fuzzy-c-means family, which is designed to cluster time- series and is particularly suited for short time-series and those with unevenly spaced sampling points. Expand
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Minimum Information About a Simulation Experiment (MIASE)
The Minimum Information Required in the Annotation of Models (MIRIAM) guidelines promote the exchange and reuse of biochemical computational models. Expand
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The road from systems biology to systems medicine
As research institutions prepare roadmaps for “systems medicine,” we ask how this differs from applications of systems biology approaches in medicine and what we (should) have learned from about oneExpand
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Systems Biology: the Reincarnation of Systems Theory Applied in Biology?
  • O. Wolkenhauer
  • Biology, Computer Science
  • Briefings Bioinform.
  • 1 September 2001
We review the domain of systems theory, its application to biology and the lessons that can be learned from the work of Robert Rosen. Expand
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A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture
We present an ordinary differential equation model combining the metabolic network governing solvent production with regulation at the genetic level of the enzymes required for this process. Expand
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Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway.
In this study, we propose a system-theoretic approach to the analysis and quantitative modeling of the TNFalpha-mediated NF-kappaB-signaling pathway. Tumor necrosis factor alpha (TNFalpha) is aExpand
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Glucose de‐repression by yeast AMP‐activated protein kinase SNF1 is controlled via at least two independent steps
The AMP‐activated protein kinase, AMPK, controls energy homeostasis in eukaryotic cells but little is known about the mechanisms governing the dynamics of its activation/deactivation. The yeast AMPK,Expand
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Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma
WEE1 kinase has been described as a major gate keeper at the G2 cell cycle checkpoint and to be involved in tumour progression in different malignant tumours. Here we analysed the expression levelsExpand
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