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Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart
The G protein-coupled apelin receptor regulates important processes of the cardiovascular homeostasis, including cardiac development, cardiac contractility, and vascular tone. Most recently, a novelExpand
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Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides.
BACKGROUND The N-terminal fragments of A- and B-type natriuretic peptides (NT-proANP and NT-proBNP) are powerful markers of cardiac function. The current assays require refinement with regard toExpand
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Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion.
We administered ghrelin, a novel growth hormone-releasing hormone, to isolated perfused rat hearts, coronary arterioles, and cultured neonatal cardiomyocytes to determine its effects on coronaryExpand
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Pressure Overload Increases GATA4 Binding Activity via Endothelin-1
Background —The signaling cascades responsible for the activation of transcription factors in the hypertrophic growth of cardiac myocytes during hemodynamic overload are largely unknown. Several ofExpand
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Intrapericardial infusion of endothelin-1 induces ventricular arrhythmias in dogs.
OBJECTIVES Recently, extremely high levels of endothelin-1 (ET-1) were detected in the pericardial fluid of patients with heart disease; however, the pathophysiological importance of this finding isExpand
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Regulation of ventricular atrial natriuretic peptide release in hypertrophied rat myocardium. Effects of exercise.
Left ventricular hypertrophy is characterized by stimulation of ventricular synthesis of atrial natriuretic peptide (ANP). This study was designed to test the hypothesis that the increasedExpand
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Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides.
Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in multiple cellular processes. In the heart, PKC signaling is involved in hypertrophic agonist-induced geneExpand
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Passive mechanical stretch releases atrial natriuretic peptide from rat ventricular myocardium.
Ventricular hypertrophy is characterized by augmentation of synthesis, storage, and release of atrial natriuretic peptide (ANP) from ventricular tissue, but the physiological stimulus for ANP releaseExpand
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Endothelin-1 Contributes to the Frank-Starling Response in Hypertrophic Rat Hearts
Abstract—Endothelin-1 is involved in mechanical load–induced cardiac growth processes; it also has effects on contractility. The interaction of endothelin-1 and the Frank-Starling response isExpand
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Collagen XV Is Necessary for Modeling of the Extracellular Matrix and Its Deficiency Predisposes to Cardiomyopathy
Rationale: The extracellular matrix (ECM) is a major determinant of the structural integrity and functional properties of the myocardium in common pathological conditions, and changes in vasculatureExpand
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