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Study of the oxidative stress in a rat model of chronic brain hypoperfusion
TLDR
The ascorbate as a major antioxidant in brain seems to be useful in monitoring chronic cerebral hypoperfusion and biochemical measurements of oxidative phosphorylation parameters were performed. Expand
Spice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension
TLDR
Results show that independent administration of curcumin is more effective in preventing negative changes in blood vessel morphology accompanying hypertensive disease. Expand
Effect of PUFA-rich plant oil on risk factors of STZ-induced diabetes in Wistar rats
TLDR
It is suggested that the plant oil with high concentrations of n-6 PUFA – linoleic acid, acts prooxidatively when administered to the rats, as well as on antioxidant enzyme activities in male Wistar rats with streptozotocin-induced diabetes. Expand
PAMAM G4 dendrimers lower high glucose but do not improve reduced survival in diabetic rats.
TLDR
The results provide the first in vivo evidence that PAMAM G4 is able to lower plasma glucose and suppress long-term markers of diabetic hyperglycaemia, and this beneficial influence cannot override PAMam G4 cytotoxic effects in the increased mortality of streptozotocin-diabetic rats. Expand
High glucose contributes to aspirin insensitivity in streptozotocin-diabetic rats: a multiparametric aggregation study
TLDR
It is concluded that chronic hyperglycaemia interferes with preventive effects of ASA on platelet reactivity and validate the suggestion that the relationship between aspirin ineffectiveness and poor metabolic control, first revealed in humans, concerns also other animals' platelets and holds regardless of the model or type of diabetes. Expand
Effects of anabolic steroids and antioxidant vitamins on ethanol-induced tissue injury.
TLDR
Histological outcomes showed a protective effect of antioxidants on hepatic and cerebellar injury caused by chronic ethanol intake and anabolic steroids protected especially the central nervous tissue against the toxicity of alcohol. Expand
Calcium signaling-mediated endogenous protection of cell energetics in the acutely diabetic myocardium.
TLDR
The results indicate that the amplification of calcium transients in the diabetic heart is associated with an increase in their amplitude and that radical-induced changes in mitochondria predominantly concern the respiratory chain and have no appreciable effect on the fluidity of the mitochondrial membranes. Expand
Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.
TLDR
Oral administration of piperine is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration, probably caused by the blockage of voltage-dependent calcium channels and supported by filamentous actin disassembly. Expand
Does long-term androgen deficiency lead to metabolic syndrome in middle-aged rats?
TLDR
The results suggest that long‐term hypogonadism started before puberty does not induce metabolic syndrome in middle‐aged male rats, but may affect the liver. Expand
Can we use adenosine diphosphate (ADP) to study "aspirin resistance"? The Janus faces of ADP-triggered platelet aggregation.
TLDR
It appears that only low ADP concentrations (up to 0.5 microM) induce TXA(2)-dependent rat platelet aggregation, which suggests that ADP could be considered a useful platelet agonist for monitoring of ASA-mediated platelet inhibition only if used at much lower concentrations than those commonly employed. Expand
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