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Study of the oxidative stress in a rat model of chronic brain hypoperfusion
- S. Kašparová, V. Brezová, +6 authors D. Dobrota
- Medicine, Chemistry
- Neurochemistry International
- 1 June 2005
The ascorbate as a major antioxidant in brain seems to be useful in monitoring chronic cerebral hypoperfusion and biochemical measurements of oxidative phosphorylation parameters were performed. Expand
Spice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension
- L. Hlavacková, A. Janegová, O. Uličná, P. Janega, A. Černá, P. Babál
- Nutrition & metabolism
- 17 October 2011
Results show that independent administration of curcumin is more effective in preventing negative changes in blood vessel morphology accompanying hypertensive disease. Expand
Effect of PUFA-rich plant oil on risk factors of STZ-induced diabetes in Wistar rats
- M. Kopál, I. Ondrejovičová, +4 authors J. Muchova
- Chemistry, Medicine
- Redox report : communications in free radical…
- 22 May 2014
It is suggested that the plant oil with high concentrations of n-6 PUFA – linoleic acid, acts prooxidatively when administered to the rats, as well as on antioxidant enzyme activities in male Wistar rats with streptozotocin-induced diabetes. Expand
PAMAM G4 dendrimers lower high glucose but do not improve reduced survival in diabetic rats.
- M. Labieniec, O. Uličná, +5 authors C. Watala
- International journal of pharmaceutics
- 19 November 2008
The results provide the first in vivo evidence that PAMAM G4 is able to lower plasma glucose and suppress long-term markers of diabetic hyperglycaemia, and this beneficial influence cannot override PAMam G4 cytotoxic effects in the increased mortality of streptozotocin-diabetic rats. Expand
High glucose contributes to aspirin insensitivity in streptozotocin-diabetic rats: a multiparametric aggregation study
- C. Watala, O. Uličná, +4 authors J. Drzewoski
- Blood coagulation & fibrinolysis : an…
- 1 March 2006
It is concluded that chronic hyperglycaemia interferes with preventive effects of ASA on platelet reactivity and validate the suggestion that the relationship between aspirin ineffectiveness and poor metabolic control, first revealed in humans, concerns also other animals' platelets and holds regardless of the model or type of diabetes. Expand
Effects of anabolic steroids and antioxidant vitamins on ethanol-induced tissue injury.
Histological outcomes showed a protective effect of antioxidants on hepatic and cerebellar injury caused by chronic ethanol intake and anabolic steroids protected especially the central nervous tissue against the toxicity of alcohol. Expand
Calcium signaling-mediated endogenous protection of cell energetics in the acutely diabetic myocardium.
- A. Ziegelhoeffer, I. Waczulíková, +9 authors J. Mujkosová
- Chemistry, Medicine
- Canadian journal of physiology and pharmacology
- 18 December 2009
The results indicate that the amplification of calcium transients in the diabetic heart is associated with an increase in their amplitude and that radical-induced changes in mitochondria predominantly concern the respiratory chain and have no appreciable effect on the fluidity of the mitochondrial membranes. Expand
Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.
- L. Hlavacková, A. Urbanová, O. Uličná, P. Janega, A. Černá, P. Babál
- Bratislavske lekarske listy
Oral administration of piperine is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration, probably caused by the blockage of voltage-dependent calcium channels and supported by filamentous actin disassembly. Expand
Does long-term androgen deficiency lead to metabolic syndrome in middle-aged rats?
- V. Borbélyová, E. Domonkos, +6 authors P. Celec
- Biology, Medicine
- Experimental Gerontology
- 1 November 2017
The results suggest that long‐term hypogonadism started before puberty does not induce metabolic syndrome in middle‐aged male rats, but may affect the liver. Expand
Can we use adenosine diphosphate (ADP) to study "aspirin resistance"? The Janus faces of ADP-triggered platelet aggregation.
- M. Dobaczewski, J. Golanski, +7 authors C. Watala
- Chemistry, Medicine
- Pharmacological reports : PR
- 1 May 2008
It appears that only low ADP concentrations (up to 0.5 microM) induce TXA(2)-dependent rat platelet aggregation, which suggests that ADP could be considered a useful platelet agonist for monitoring of ASA-mediated platelet inhibition only if used at much lower concentrations than those commonly employed. Expand