O. Ukkola

Publications223
h-index48
Citations7,044
Highly Influential Citations251
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Role of ghrelin polymorphisms in obesity based on three different studies.
TLDR
The preproghrelin Met72 carrier status seems to be protective against fat accumulation and associated metabolic comorbidities.
Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes.
TLDR
It is concluded that low ghrelin is independently associated with type 2 diabetes, insulin concentration, insulin resistance, and elevated BP, and might have some role in the etiology of type 1 diabetes and the regulation of BP.
Mutations in the preproghrelin/ghrelin gene associated with obesity in humans.
TLDR
Evidence is provided that a low frequency sequence variation in the ghrelin gene could play a role in the etiology of obesity.
Adiponectin: a link between excess adiposity and associated comorbidities?
TLDR
It is shown that adiponectin has anti-inflammatory and antiatherogeneic effects as well as multiple beneficial effects on metabolism, and is shown to suppress macrophage-to-foam cell transformation and has an inhibitory effect on vascular smooth muscle cell proliferation.
Age, body mass index, race and other determinants of steroid hormone variability: the HERITAGE Family Study.
TLDR
It is concluded that age was the most important factor, followed by BMI, race and lifestyle factors in explaining steroid hormone variability.
Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects
TLDR
The ghrelin 51Gln allele was a risk factor for Type 2 diabetes, and the effect remained significant after adjustment for age, BMI, and study group, while the low IGF-I concentrations in 51GlN carriers suggest that the mechanism might be associated with low GH concentrations.
Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort.
TLDR
The results do not support the prevailing notion that sequence variation in the melanocortin 4 receptor gene is a frequent cause of human obesity.
Resistin - a mediator of obesity-associated insulin resistance or an innocent bystander?
  • O. Ukkola
  • Medicine, Biology
    European journal of endocrinology
  • 1 November 2002
TLDR
In conclusion, resistin is a fascinating new hormone for which a definite role in metabolism will be revealed in the near future.
Low plasma adiponectin concentration is an indicator of the metabolic syndrome.
TLDR
Investigation of the role of adiponectin as a biomarker of metabolic syndrome (MS) and how the plasma adiponECTin levels relate to new criteria of MS proposed by the International Diabetes Federation concludes that adip onectin levels correlate with most of the components of the MS and the metabolic cluster per se.
Lack of association between polymorphisms of catalase, copper–zinc superoxide dismutase (SOD), extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patients with type…
TLDR
Lack of association between polymorphisms of catalase, copper–zinc superoxide dismutase, extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patients with type 2 diabetes mellitus is found.
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