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Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different
TLDR
A fast, sensitive and easily applicable GC-MS assay for the chiral quantification of the highly toxic organophosphorus compound tabun in hemolysed swine blood for further use in toxicokinetic and toxicodynamic studies is developed and validated. Expand
Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase.
TLDR
The results show a large difference in the inhibitory potency between (-)- and (+)-tabun and provide further insight into the kinetic interactions between tabun enantiomers and AChE and may contribute to the development of more effective treatment options. Expand
Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with
TLDR
The validated assay was successfully applied to several authentic plasma samples from patients treated or intoxicated with various benzodiazepines or with zaleplone, zolpidem or zopiclone, and has proven to be appropriate for the isolation, separation, screening, identification and quantification of the drugs mentioned above in plasma. Expand
Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical
TLDR
The liquid chromatographic-mass spectrometric assay was successfully applied to authentic plasma samples allowing confirmation of diagnosis of overdose situations as well as monitoring of patients' compliance. Expand
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
TLDR
The modified biological assay is appropriate for the initial semi-quantitative screening of candidate compounds for the detoxification of nerve agents and the beta-cyclodextrin derivative CD-IBA demonstrated its ability to detoxify different nerve agents. Expand
Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups.
TLDR
Results show that attachment of pyridinium-derived substituents with an aldoxime group in 3- or 4-position to a β-cyclodextrin ring affords active compounds mediating tabun degradation and provide evidence that the mode of action of the cyclodextrine involves covalent modification of its oxime group rendering the scavenger inactive after reaction with the first tabun molecule. Expand
Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration.
TLDR
The results demonstrate a rather rapid elimination of tabun enantiomers in vivo and may provide a toxicokinetic basis for the further development and optimization of medical countermeasures against this nerve agent. Expand
The diagnostic value of determining the hydroxy metabolite of glimepiride (M1) in blood serum in cases of severe hypoglycaemia associated with glimepiride therapy
TLDR
The data suggest that M1 plays no significant causal role in prolonged SH, and it appears unlikely that genetic polymorphisms in the cytochrome P450 enzyme CYP2C9 could have contributed to a low clearance of glimepiride in the present patients. Expand