O. Tanaka

Publications76
h-index17
Citations1,550
Highly Influential Citations41
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Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium.
Degradation of proteoglycans is an initial change in osteoarthritic cartilage. Matrix metalloproteinase-3 (MMP-3; stromelysin) capable of degrading cartilage proteoglycans and type IX collagen was… Expand
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Compressive force promotes sox9, type II collagen and aggrecan and inhibits IL-1beta expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells.
The initial modeling and subsequent development of the skeleton is controlled by complex gene-environment interactions. Biomechanical forces may be one of the major epigenetic factors that determine… Expand
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Quantitative Analysis of Gymnemic Acids by High Performance Liquid Chromatography
ギムネマ酸の定量法を検討した結果,試料を1%KOH及びそれに続く0.5 N-HClで加水分解を行いgymnemageninへ変換し, HPLCで定量する方法を確立した.この定量値をギムネマ酸の中で主要な成分であるgymnemic acid… Expand
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Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in…
Vasoactive intestinal peptide (VIP), a 28-amino acid peptide hormone, plays many physiological roles in the peripheral and central nervous systems. It has been proposed that endogenous VIP released… Expand
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Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.
We previously isolated from a rat regenerating islet cDNA library a gene named Reg, which is expressed in regenerating islets but is not expressed in normal islets. Here we examined the effect of rat… Expand
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Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice.
Cyclic ADP-ribose (cADPR) serves as a second messenger for Ca2+ mobilization in insulin secretion, and CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activities (Takasawa, S., Tohgo, A.,… Expand
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N.m.r. spectral study of α- and β-l-arabinofuranosides
Abstract Anomeric pairs of l -arabinofuranosides of various aliphatic alcohols were synthesized and then investigated by n.m.r. spectroscopy. The 13 C-n.m.r. glycosylation shift of these l… Expand
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Localization of mRNAs for three novel members (β3, β4 and γ2) of phospholipase C family in mature rat brain
Abstract In mature rat brain, PLC β3 mRNA was detected weakly only in the pituitary gland and the cerebellar Purkinje and granule cells whereas PLC β4 mRNA was expressed intensely in the olfactory… Expand
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Adenovirus-mediated ectopic expression of Msx2 in even-numbered rhombomeres induces apoptotic elimination of cranial neural crest cells in ovo.
Distinct cranial neural crest-derived cell types (a number of neuronal as well as non-neuronal cell lineages) are generated at characteristic times and positions in the rhombomeres of the hindbrain… Expand
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BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways
The effect of neurotrophic factors on apoptosis induced by ionomycin, a potent Ca2+ ionophore, was investigated using cultured cortical neurons from embryonic rats. Brain-derived neurotophic factor… Expand
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