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TRANS-3′-HYDROXYCOTININE O- AND N-GLUCURONIDATIONS IN HUMAN LIVER MICROSOMES
Results suggest that trans-3′-hydroxycotinine O-glucuronosyltransferase activity in human liver microsomes would be mainly catalyzed by UGT1A4, which is a major metabolite of nicotine in humans.
Acid-induced conformational alteration of cis-preferential aromatic amides bearing N-methyl-N-(2-pyridyl) moiety
Acid-induced conformational switching of aromatic N-methyl-N-(2-pyridyl)amides
Acid-induced molecular folding and unfolding of N-methyl aromatic amide bearing 2,6-disubstituted pyridines.
The structural features and conformational conversion of the N-methyl pyridyl amide oligomer bearing 2,6-disubstituted pyridsines were investigated and revealed that the environment-responsive type of conformational control can be performed.
Synthesis of maremycins A and D1 via cycloaddition of a nitrone with (E)-3-ethylidene-1-methylindolin-2-one.
A concise synthesis of maremycins A and D1 has been accomplished via cycloaddition of a chiral cyclic nitrone with ( E)-3-ethylidene-1-methylindolin-2-one as a key step, suitable for large-scale synthesis for biological screening.
Redox-responsive conformational alteration of aromatic amides bearing N-quinonyl system
Total syntheses of tubulysins.
The total syntheses of tetrapeptides tubulysins U, U, and V, which are potent tubulin polymerization inhibitors, are accomplished by using these methodologies, in which the isoxazolidine ring was used as the effective protective group for γ-amido alcohol functionality.
Acid-induced molecular-structural transformation of N-methyl aromatic oligoamides bearing pyridine-2-carboxamide
Total synthesis of grandisine D.
Total synthesis of grandisine D (5) was achieved by a Brønsted acid mediated Morita-Baylis-Hillman (MBH) ring-closure reaction and stereoselective aldol condensation with (S)-5-methylcyclohexenone…