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Modern Alkaloids : Structure, Isolation, Synthesis and Biology
The structure and pharmacological properties of Alkaloid-like Compounds and their applications in Clinical Use or in Clinical Trials are described.
Phytocannabinoids: a unified critical inventory.
- L. Hanuš, Stefan Meyer, E. Muñoz, O. Taglialatela‐Scafati, G. Appendino
- Environmental ScienceNatural product reports
- 23 November 2016
The integrated inventory of these compounds and their biological macromolecular end-points highlights the opportunities that phytocannabinoids offer to access desirable drug-like space beyond the one associated to the narcotic target CB1.
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
The California bay laurel or Umbellularia californica (Hook. & Arn.) Nutt., is known as the 'headache tree' because the inhalation of its vapours can cause severe headache crises. However, the…
Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and…
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of…
Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites
Results indicate longamide B and dibromopalau’amine (11) to be promising trypanocidal and antileishmanial agents, while dispacamide B (3) and spongiacidin B (6) emerge as antimalarial lead compounds.
Cannabinoids: occurrence and medicinal chemistry.
- G. Appendino, G. Chianese, O. Taglialatela‐Scafati
- ChemistryCurrent medicinal chemistry
- 28 February 2011
A survey of the more recent advances in both phytochemistry of C. sativa, the medicinal chemistry of cannabinoids, and their distribution in plants is given, highlighting the impact that research in these hot fields could have for modern medicinal chemistry and pharmacology.
Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex.
- E. Fattorusso, S. Parapini, Claudio Campagnuolo, N. Basilico, O. Taglialatela‐Scafati, D. Taramelli
- Chemistry, BiologyThe Journal of antimicrobial chemotherapy
- 1 December 2002
Evaluated in vitro the antimalarial activity of the major cycloperoxides extracted from the sponge Plakortis simplex, and the activity of plakortin and dihydroplakortsin was significantly higher against chloroquine-resistant than chloroquin-susceptible parasites, following a pattern similar to that of artemisinin, although they were 50-fold less active.
Chemical composition, antimicrobial and antioxidant activities of anethole-rich oil from leaves of selected varieties of fennel [Foeniculum vulgare Mill. ssp. vulgare var. azoricum (Mill.) Thell].
Chemical composition of shallot (Allium ascalonicum Hort.).
- E. Fattorusso, M. Iorizzi, V. Lanzotti, O. Taglialatela‐Scafati
- ChemistryJournal of agricultural and food chemistry
- 23 August 2002
An extensive phytochemical analysis of the polar extracts from bulbs of shallot, Allium ascalonicum Hort., led to the isolation of two new furostanol saponins, named ascalonicoside A1/A2 (1a/1b) and…
Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors.
- A. Ahmed-Belkacem, S. Macalou, A. di Pietro
- Chemistry, BiologyJournal of medicinal chemistry
- 7 March 2007
The present study provides the first data on the B CRP-inhibiting activity of rotenoid derivatives, indicating boeravinones as a new class of interesting BCRP inhibitors.