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Exercise‐induced diaphragmatic fatigue in healthy humans.
1. Twelve healthy subjects (33 +/‐ 3 years) with a variety of fitness levels (maximal oxygen uptake (VO2, max) = 61 +/‐ 4 ml kg‐1 min‐1, range 40‐80), exercised at 95 and 85% VO2, max to exhaustionExpand
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Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury
Background Main contributors to adverse outcomes in severely burned pediatric patients are profound and complex metabolic changes in response to the initial injury. It is currently unknown how longExpand
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Respiratory management of inhalation injury.
Advances in the care of patients with major burns have led to a reduction in mortality and a change in the cause of their death. Burn shock, which accounted for almost 20 percent of burn deaths inExpand
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Pathophysiologic Response to Severe Burn Injury
Objective:To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial. SummaryExpand
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Hypoxic effects on exercise-induced diaphragmatic fatigue in normal healthy humans.
We examined the effects of hypoxia on exercise-induced diaphragmatic fatigue. Eleven subjects with a mean maximal O2 uptake of 52.4 +/- 0.7 ml.kg-1.min-1 completed one normoxic (arterial O2Expand
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Contribution of diaphragmatic power output to exercise-induced diaphragm fatigue.
In nine normal humans we compared the effects on diaphragm fatigue of whole body exercise to exhaustion (86-93% of maximal O2 uptake for 13.2 +/- 2.0 min) to voluntary increases in the tidal integralExpand
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Effects of a 12-wk resistance exercise program on skeletal muscle strength in children with burn injuries.
The posttraumatic response to burn injury leads to marked and prolonged skeletal muscle catabolism and weakness, which persist despite standard rehabilitation programs of occupational and physicalExpand
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Long-Term Propranolol Use in Severely Burned Pediatric Patients: A Randomized Controlled Study
Objective:To determine the safety and efficacy of propranolol given for 1 year on cardiac function, resting energy expenditure, and body composition in a prospective, randomized, single-center,Expand
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Five-year outcomes after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy.
BACKGROUND Oxandrolone, an anabolic agent, has been administered for 1 year post burn with beneficial effects in pediatric patients. However, the long-lasting effects of this treatment have not beenExpand
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The Metabolic Stress Response to Burn Trauma: Current Understanding and Therapies
Summary Severe burns incur a profound stress response, which is unrivaled in terms of its magnitude and duration. Recent evidence suggests that the pathophysiological stress response to severe burnsExpand
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