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Molecular analysis of the emergence of pandemic Vibrio parahaemolyticus
TLDR
The data show that there is considerable genomic flux in this species and that the new highly virulent clone arose from an O3:K6 isolate that acquired at least seven novel regions, which included both a T3SS and a T6SS.
Multilocus Sequence Typing Compared to Pulsed-Field Gel Electrophoresis for Molecular Typing of Pseudomonas aeruginosa
TLDR
P pulsed-field gel electrophoresis was more discriminatory than MLST for determining genetic differences in P. aeruginosa, and while MLST was better for detecting genetic relatedness, PFGE was more discriminated against.
Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites.
TLDR
Chloroquine-susceptible parasites that predominate in Malawi likely represent a reexpansion of the susceptible parasites that survived in the population despite widespread drug pressure in the region.
Assessment of Evolution of Pandemic Vibrio parahaemolyticus by Multilocus Sequence Typing
ABSTRACT The genetic relatedness of 81 isolates of Vibrio parahaemolyticus was assessed by multilocus sequence typing. The strain with serotype O3:K6 emerged as a pandemic pathogen in 1996, with
Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition
TLDR
Overall genus-level microbiota composition exhibit a shift in controls from low to high levels of Prevotella and in MSD cases from high to low levels of Escherichia/Shigella in younger versus older children; however, there was significant variation among many genera by both site and age.
Prospective cohort study of mother‐to‐infant infection and clearance of hepatitis C in rural Egyptian villages
TLDR
This study found 15.7% and 10.9% of pregnant women had HCV antibodies (anti‐HCV) and HCV‐RNA, respectively, and investigating how infants clear infection may provide important information about protective immunity to HCV.
Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia
TLDR
The most recently discoveredAstrovirus, MLB3, was the most prevalent and was found more commonly in control stools in The Gambia, while astrovirus MLB1 was associated with diarrhea in Kenya, and 3 unanticipated avian or canine astroviruses in the human stool samples were noted.
Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence
TLDR
The data support the idea that the pandemic strains are closely related and that recent South American outbreaks of foodborne disease caused by V. parahaemolyticus are closely linked to outbreaks in India.
A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa
TLDR
Pyrosequencing in conjunction with a haplotype-estimating algorithm provides accurate estimates of haplotypes present in infections with up to 3 haplotypes, and can be used to monitor genetic diversity in parasite populations prior to and following introduction of MSP-1-based malaria vaccines.
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