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Pungent products from garlic activate the sensory ion channel TRPA1.
- D. Bautista, P. Movahed, P. Zygmunt
- BiologyProceedings of the National Academy of Sciences…
- 23 August 2005
It is shown that allicin and DADS excite an allyl isothiocyanate-sensitive subpopulation of sensory neurons and induce vasodilation by activating capsaicin-sensitive perivascular sensory nerve endings, suggesting that garlic excites sensory neurons primarily through activation of TRPA1.
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.
The antinociceptive effects of spinal and systemic administration of acetaminophen are shown to be lost in Trpa1(-/-) mice and spinal TRPA1 activation is disclosed as a potential pharmacological strategy to alleviate pain.
Endogenous Unsaturated C18 N-Acylethanolamines Are Vanilloid Receptor (TRPV1) Agonists*
- P. Movahed, B. Jönsson, E. Högestätt
- Biology, ChemistryJournal of Biological Chemistry
- 18 November 2005
It is shown that several endogenous non-cannabinoid NAEs, many of which are more abundant than anandamide in rat tissues, activate TRPV1 and thus may play a role as endogenous TRPv1 modulators.
Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice
- Lovisa Heyman, Ulrika Axling, N. Blanco, O. Sterner, C. Holm, K. Berger
- MedicineJournal of nutrition and metabolism
- 14 January 2014
Lingenberries were shown to fully or partially prevent the detrimental metabolic effects induced by high-fat diet, and it is proposed that the beneficial metabolic effects of lingonberries could be useful in preventing obesity and related disorders.
Secondary metabolites with nematicidal and antimicrobial activity from nematophagous fungi and Ascomycetes
Screening of nematode-trapping fungi for antimicrobial and nematicidal activities gave three new antimicrobial metabolites from cultures of five Arthrobotrys strains, suggesting that the same biosynthetic pathways function in both the teleomorph and anamorph.
Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum.
Arzanol inhibited HIV-1 replication in T cells and the release of pro-inflammatory cytokines in LPS-stimulated primary monocytes, qualifying as a novel plant-derived anti-inflammatory and antiviral chemotype worth further investigation.
Fatty acids and other compounds with nematicidal activity from cultures of Basidiomycetes.
In a screening for nematicidal activities in cultures of Basidiomycetes, cultures of Pleurotus pulmonarius and Hericium coralloides exhibited toxic effects towards the saprophytic nematode Caenorhabditis elegans, with the most active compounds being 1 and 2 with LD50 values between 5 and 10 ppm.
Novel natural vanilloid receptor agonists: new therapeutic targets for drug development.
Oligomeric acylphloroglucinols from myrtle (Myrtus communis).
- G. Appendino, Federica Bianchi, A. Minassi, O. Sterner, M. Ballero, S. Gibbons
- ChemistryJournal of natural products
- 19 February 2002
The dimeric nonprenylated acylphloroglucinol semimyrtucommulone was obtained from the leaves of myrtle as a 2:1 mixture of two rotamers and showed significant antibacterial activity against multidrug-resistant clinically relevant bacteria.