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Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.
TLDR
The opposite effects of the rab5 Q79L and S34N mutants suggest that rab5:GTP is required prior to membrane fusion, whereas GTP hydrolysis by rab5 occurs after membrane fusion and functions to inactivate the protein.
EEA1, an Early Endosome-Associated Protein.
TLDR
It is proposed that EEA1 is required for vesicular transport of proteins through early endosomes and that its finger motifs are required for this activity.
The Salmonella-containing vacuole: moving with the times.
TLDR
It is apparent that SCV biogenesis is an extremely dynamic process involving; extensive membrane remodeling, interactions with the endolysosomal pathway, actin rearrangements and microtubule-based movement and tubule extension.
Biogenesis of Salmonella typhimurium‐containing vacuoles in epithelial cells involves interactions with the early endocytic pathway
TLDR
This study indicates that intracellular S. typhimurium occupies a unique niche, branching away from the traditional endocytic pathway between the early and late endosomal compartments.
Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages
TLDR
This study has found that fusion of the endoplasmic reticulum (ER) with the macrophage plasmalemma, underneath phagocytic cups, is a source of membrane for phagosome formation in macrophages.
Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia
TLDR
It is demonstrated that a subpopulation of Salmonella hyperreplicating in the cytosol of epithelial cells serves as a reservoir for dissemination and provides a mechanistic explanation for the mucosal inflammation that is triggered duringSalmonella infection of the gastrointestinal and biliary tracts.
Activation of Akt/Protein Kinase B in Epithelial Cells by theSalmonella typhimurium Effector SigD*
TLDR
It is found that Akt is activated by Salmonella enterica serovar Typhimurium in epithelial cells and SigD is the first bacterial effector to be identified as an activator of Akt.
Chlamydial IFN-gamma immune evasion is linked to host infection tropism.
TLDR
Findings show chlamydial host infection tropism is determined by IFN-gamma-mediated immunity.
The rab7 GTPase controls the maturation of Salmonella typhimurium‐containing vacuoles in HeLa cells
TLDR
Results indicate that rab7 regulates SCV biogenesis during the phase characterized by the rapid acquisition of lysosomal proteins, and proposes that SCV maturation involves its interaction with rab7/Lgp‐containing vesicles which are possible intermediate cargo components of the late endocytic pathway.
A synaptojanin‐homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation
TLDR
A region near the carboxyl‐terminus of SigD is characterized which is important for phosphatase activity, and how dephosphorylation of inositol phospholipids by SigD in vivo might contribute to the activation of Akt is discussed.
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