The Norwegian General Practice (NORGEP) criteria for assessing potentially inappropriate prescriptions to elderly patients
- S. Rognstad, M. Brekke, A. Fetveit, O. Spigset, T. Wyller, J. Straand
- Medicine, Political ScienceScandinavian Journal of Primary Health Care
- 1 January 2009
The NORGEP criteria may serve as rules of thumb for general practitioners related to their prescribing practice for elderly patients, and as a tool for evaluating the quality of GPs’ prescribing in settings where access to clinical information for individual patients is limited, e.g. in prescription databases and quality improvement interventions.
Norwegian medical students’ attitudes towards the pharmaceutical industry
There were considerable differences in the students’ attitudes between universities, suggesting that medical students are prone to influence from university lecturers.
Incidence of fatal adverse drug reactions: a population based study.
- K. Wester, A. Jönsson, O. Spigset, H. Druid, S. Hägg
- Medicine, BiologyBritish Journal of Clinical Pharmacology
- 1 April 2008
Haemorrhages were seen in a majority of the FADRs; antithrombotic agents or NSAIDs were implicated in most of these events; preventive measures should be taken to reduce the number of deaths caused by drugs.
Pregnancy Outcome After Exposure to Antidepressants and the Role of Maternal Depression: Results From the Norwegian Mother and Child Cohort Study
- H. Nordeng, M. M. van Gelder, O. Spigset, G. Koren, A. Einarson, M. Eberhard‐Gran
- Medicine, PsychologyJournal of Clinical Psychopharmacology
- 1 April 2012
This study does not suggest a strongly increased risk of malformations, preterm birth, or low birth weight following prenatal exposure to antidepressants after adjustments for level of maternal depression and various sociodemographic and lifestyle factors.
Medication use in pregnancy: a cross-sectional, multinational web-based study
The majority of women in Europe, North America, South America and Australia used at least one medication during pregnancy, and there was a substantial inter-region variability in the types of medication used.
Serum Concentrations of Antidepressant Drugs in a Naturalistic Setting: Compilation Based on a Large Therapeutic Drug Monitoring Database
- M. Reis, T. Aamo, O. Spigset, J. Ahlner
- Medicine, PsychologyTherapeutic Drug Monitoring
- 1 February 2009
By presenting a comprehensive compilation of therapeutic drug monitoring data for each drug, a reference tool is created, in addition to improved pharmacokinetic knowledge of antidepressant drugs, and patients older than 65 years had higher serum concentrations than the younger ones for all drugs except amitriptyline, moclobemide, and trimipramine.
Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole)
Based on sales data and spontaneous reporting of adverse drug reactions in Sweden, the risk of agranulocytosis with dipyrone seems to be considerably higher than the previously estimated risks.
Adverse Reactions of Selective Serotonin Reuptake Inhibitors
- O. Spigset
- Medicine, PsychologyDrug Safety
- 1 March 1999
Investigating the pattern of adverse reactions reported on SSRIs in Sweden found that the median SSRI dosages were above average in patients experiencing seizures, hypomania/mania, personality changes, malaise, bodyweight gain, gynaecomastia and hyperprolactinaemia/galactorrhoea.
Gender differences in drug effects: implications for anesthesiologists
Background: The gender aspect in pharmacokinetics and pharmacodynamics of anesthetics has attracted little attention. Knowledge of previous work is required to decide if gender‐based differences in…
Hyponatraemia and the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Induced by Psychotropic Drugs
The acute treatment of SIADH induced by a psychotropic drug includes discontinuation of the drug as well as restriction of fluid intake, and concomitant treatment with demeclocycline may reduce the tendency of hyponatraemia.