• Publications
  • Influence
Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy
Lafora's disease (LD; OMIM 254780) is an autosomal recessive form of progressive myoclonus epilepsy characterized by seizures and cumulative neurological deterioration. Onset occurs during lateExpand
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Neuromagnetic imaging of movement-related cortical oscillations in children and adults: Age predicts post-movement beta rebound
We measured visually-cued motor responses in two developmentally separate groups of children and compared these responses to a group of adults. Expand
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Practice Parameter: Medical Treatment of Infantile Spasms
Objective: To determine the current best practice for treatment of infantile spasms in children. Methods: Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference listsExpand
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Focal resection of fast ripples on extraoperative intracranial EEG improves seizure outcome in pediatric epilepsy
Purpose:  High‐frequency oscillations (HFOs), termed ripples at 80–200 Hz and fast ripples (FRs) at >200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a valuable surrogateExpand
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Dynamic Changes of Ictal High‐Frequency Oscillations in Neocortical Epilepsy: Using Multiple Band Frequency Analysis
Summary:  Purpose: To characterize the spatial and temporal course of ictal high‐frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy.
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Basic mechanisms of generalized absence seizures
  • O. Snead
  • Medicine
  • Annals of neurology
  • 1 February 1995
Generalized absence seizures are neurophysiologically, pharmacologically, and developmentally unique and comprise the primary seizure type in a number of different absence epilepsy syndromes. OverExpand
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High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
OBJECTIVE To compare the efficacy of corticotropin (ACTH) (150 U/m2/day) and prednosone (2 mg/kg/day) given for 2 weeks, in suppressing clinical spasms and hypsarrhythmic electroencephalogram (EEG)Expand
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Cortical dysplastic lesions in children with intractable epilepsy: role of complete resection.
OBJECT The authors conducted a study to determine seizure-related outcomes in a group of pediatric patients with pathologically proven focal cortical dysplasia (FCD) treated by focal corticalExpand
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Dysembryoplastic neuroepithelial tumors in childhood
Background: Dysembryoplastic neuroepithelial tumors (DNTs) are associated with medically intractable epilepsy and a favorable prognosis after surgical resection. The authors describe the clinical,Expand
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Infantile Spasms and Down Syndrome: A New Animal Model
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a validExpand
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