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Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy
Lafora's disease (LD; OMIM 254780) is an autosomal recessive form of progressive myoclonus epilepsy characterized by seizures and cumulative neurological deterioration. Onset occurs during late… Expand
Neuromagnetic imaging of movement-related cortical oscillations in children and adults: Age predicts post-movement beta rebound
We measured visually-cued motor responses in two developmentally separate groups of children and compared these responses to a group of adults. Expand
Practice Parameter: Medical Treatment of Infantile Spasms
Objective: To determine the current best practice for treatment of infantile spasms in children. Methods: Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference lists… Expand
Focal resection of fast ripples on extraoperative intracranial EEG improves seizure outcome in pediatric epilepsy
Purpose: High‐frequency oscillations (HFOs), termed ripples at 80–200 Hz and fast ripples (FRs) at >200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a valuable surrogate… Expand
Dynamic Changes of Ictal High‐Frequency Oscillations in Neocortical Epilepsy: Using Multiple Band Frequency Analysis
Summary: Purpose: To characterize the spatial and temporal course of ictal high‐frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy.
Basic mechanisms of generalized absence seizures
- O. Snead
- Annals of neurology
- 1 February 1995
Generalized absence seizures are neurophysiologically, pharmacologically, and developmentally unique and comprise the primary seizure type in a number of different absence epilepsy syndromes. Over… Expand
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
OBJECTIVE To compare the efficacy of corticotropin (ACTH) (150 U/m2/day) and prednosone (2 mg/kg/day) given for 2 weeks, in suppressing clinical spasms and hypsarrhythmic electroencephalogram (EEG)… Expand
Cortical dysplastic lesions in children with intractable epilepsy: role of complete resection.
OBJECT The authors conducted a study to determine seizure-related outcomes in a group of pediatric patients with pathologically proven focal cortical dysplasia (FCD) treated by focal cortical… Expand
Dysembryoplastic neuroepithelial tumors in childhood
Background: Dysembryoplastic neuroepithelial tumors (DNTs) are associated with medically intractable epilepsy and a favorable prognosis after surgical resection. The authors describe the clinical,… Expand
Infantile Spasms and Down Syndrome: A New Animal Model
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid… Expand