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A vaccine that prevents pregnancy in women.
TLDR
Evidence of the feasibility of a vaccine for control of human fertility is presented, consisting of a heterospecies dimer of the beta sub unit of human chorionic gonadotropin associated noncovalently with the alpha subunit of ovine luteinizing hormone, that induces antibodies of high avidity against hCG.
The HSD‐hCG Vaccine Prevents Pregnancy in Women: Feasibility Study of a Reversible Safe Contraceptive Vaccine
TLDR
The objective is to develop a vaccine for reversible control of fertility in women and to study the immune response to the vaccine in women with low sperm count.
Gonadotropin and tumorigenesis: Direct and indirect effects on inflammatory and immunosuppressive mediators and invasion
TLDR
These studies elucidate the pathways by which hCG can promote tumorigenesis, providing further rationale for anti‐hCG vaccination in the treatment of gonadotropin‐sensitive tumors.
Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing hormone: reacting determinant and action on ovulation and estrus suppression.
TLDR
A monoclonal antibody generated against the decapeptide gonadotropin-releasing hormone (GnRH) was effective in intercepting the bioactivity of the hormone; it blocked ovulation in rats and was competent to suppress the progression of estrus in dogs, an indication that GnRH may play an inductive role in the reproductive function of dogs.
Bypass by an alternate 'carrier' of acquired unresponsiveness to hCG upon repeated immunization with tetanus-conjugated vaccine.
We report here the use of an alternative carrier diphtheria toxoid (DT) in human subjects to overcome antigen-specific unresponsiveness upon immunization with a hapten/ligand-carrier conjugate. In
Targeting vaccinia virus-expressed secretory beta subunit of human chorionic gonadotropin to the cell surface induces antibodies
TLDR
None of the animals immunized with vaccinia virus expressing the native secretory form of beta hCG showed any hCG-specific antibody response, and the anti-hCG antibody titers persisted for a long period of time (more than 6 months).
Anti‐hCG Vaccines are in Clinical Trials
Two vaccines inducing antibodies against human chorionic gonadotropin (hCG) have completed Phase I clinical trials, indicating the reversibility and safety of these vaccines. One is currently in
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