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Precision of plasma clearance of iohexol for estimation of GFR in patients with renal disease.
Findings indicate that the method of plasma clearance of iohexol allows a good precision in the estimation of GFR in patients with normal renal function and different degrees of renal dysfunction.
Prediction of cyclosporine area under the curve using a three-point sampling strategy after Neoral administration.
Accurate monitoring of cyclosporine (CsA) dosage is still a problem, because measurement of the area under the curve (AUC)--the most appropriate indicator of exposure to CsA--requires a number of
Recovery of blood mononuclear cell calcineurin activity segregates two populations of renal transplant patients with different sensitivities to cyclosporine inhibition.
Investigation of measurement of calcineurin activity in peripheral blood mononuclear cells (PBMC) from 30 renal transplant patients given CsA as a part of their immunosuppressive regimen found that it reflects the blood Cs a trough level and segregates two populations of transplanted recipients -- one with complete recovery of the enzyme activity and another that never returns to the baseline calcineuran level.
How to convert from traditional cyclosporine to the microemulsion formulation in stable renal transplant patients?
There was a tendency to lower GFR even in some patients randomized to 1:0.75 dose-ratio conversion but mostly in those with 1:1 conversion, and the Neoral formulation that permits a more effective, consistent, and predictable absorption of CsA may represent a great advantage in order to prevent acute and possibly chronic rejections.
Abbreviated kinetic profiles in area-under-the-curve monitoring of cyclosporine therapy. Technical note.
Two limited sampling strategies are compared in order to define the one that best predicts AUC after CsA-ME in 51 renal transplant recipients with stable renal function.
Pharmacokinetics and renal function after conversion from standard to microemulsion formulation of cyclosporine in stable renal transplant patients.
Evaluating the effect of changeover from Sandimmune to Neoral at a comparable trough CyA therapeutic range on CyA pharmacokinetics and on renal function in stable renal transplant patients found that Neoral may offer some advantage over Sandimmune in the monitoring of the actual exposure to CyA, which would enhance its therapeutic index.
Distribution of Chemical Elements of Iron-Gall Ink Writing Studied by the PIXE Method
SUMMARIES The chemical element profiles of iron-gall ink writing before and after water treatment and deacidification were determined. A 17th century manuscript of rag paper was used in the study.