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Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injuredExpand
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A Pericyte Origin of Spinal Cord Scar Tissue
Scars formed in response to damage to the central nervous system show unexpected complexity. There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealedExpand
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Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contributeExpand
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Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
Mitochondrial morphology is controlled by two opposing processes: fusion and fission. Drp1 (dynamin‐related protein 1) and hFis1 are two key players of mitochondrial fission, but how Drp1 isExpand
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Evidence for neurogenesis in the adult mammalian substantia nigra
New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost inExpand
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Distinct pools of synaptic vesicles in neurotransmitter release
NERVE terminals are unique among cellular secretory systems in that they can sustain vesicular release at a high rate. Although little is known about the mechanisms that account for the distinctiveExpand
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Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions.
The proline-rich COOH-terminal region of dynamin binds various Src homology 3 (SH3) domain-containing proteins, but the physiological role of these interactions is unknown. In living nerve terminals,Expand
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Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition
Lisa von Kleist, Wiebke Stahlschmidt, Haydar Bulut, Kira Gromova, Dmytro Puchkov, Mark J. Robertson, Kylie A.MacGregor, Nikolay Tomilin, Arndt Pechstein, Ngoc Chau, Megan Chircop, Jennette Sakoff,Expand
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Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice.
Synapsin I has been proposed to be involved in the modulation of neurotransmitter release by controlling the availability of synaptic vesicles for exocytosis. To further understand the role ofExpand
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Endophilin/SH3p4 Is Required for the Transition from Early to Late Stages in Clathrin-Mediated Synaptic Vesicle Endocytosis
Endophilin/SH3p4 is a protein highly enriched in nerve terminals that binds the GTPase dynamin and the polyphosphoinositide phosphatase synaptojanin, two proteins implicated in synaptic vesicleExpand
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