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New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabeticExpand
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Novel Synthetic, Salt-Resistant Analogs of Human Beta-Defensins 1 and 3 Endowed with Enhanced Antimicrobial Activity
ABSTRACT Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high saltExpand
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Genotype-phenotype correlation in cystic fibrosis: the role of modifier genes.
More than 1,000 mutations have been identified in the cystic fibrosis (CF) transmembrane regulator (CFTR) disease gene. The impact of these mutations on the protein and the wide spectrum of CFExpand
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Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool
We have designed a cyclic 17-amino acid β-defensin analog featuring a single disulfide bond. This analog, designated “AMC” (ie, antimicrobial cyclic peptide), combines the internal hydrophobic domainExpand
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Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation.
Epidemiological data suggest that obesity represent an important risk factor for asthma, but the link between excess fat and airway hyperresponsiveness (AHR) and inflammation is not fully understood.Expand
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Laboratory medicine: health evaluation in elite athletes
Abstract The need to evaluate the health status of an athlete represents a crucial aim in preventive and protective sports science in order to identify the best diagnostic strategy to improveExpand
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Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics
Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents. AntimicrobialExpand
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Chimeric Beta-Defensin Analogs, Including the Novel 3NI Analog, Display Salt-Resistant Antimicrobial Activity and Lack Toxicity in Human Epithelial Cell Lines
ABSTRACT Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are thus prime candidates as therapeutic agents directed against infective diseases. Based on theExpand
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Adiponectin profile and Irisin expression in Italian obese children: Association with insulin‐resistance
HighlightsTotal Acrp30 and HMW oligomers were lower in obese children than in controls.Irisin levels were significantly higher in obese children than in controls.Irisin levels were inverselyExpand
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Differentially expressed and activated proteins associated with non small cell lung cancer tissues
BackgroundLung cancer is a leading cause of mortality. The most common cancer subtype, non small cell lung cancer (NSCLC), accounts for 85-90 % all cases and is mainly caused by environmental andExpand
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