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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that renders human dendritic and myeloid cells largely refractory to HIV-1 infection. Here we identify SAMHD1 asExpand
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A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 millionExpand
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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein
Like other pathogenic viruses, HIV–1 down–modulates surface expression of major histocompatibility complex class I (MHC–I) molecules in infected cells, thus impairing lysis by cytotoxic TExpand
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The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
Nature 382, 833-835 (1996) THE labelling of the two lower panels of Fig. 2b was accidentally omitted. These panels showed inhibition (left panel) or lack of inhibition (right panel) of syncytiaExpand
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The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
APUTATIVE chemokine receptor that we previously cloned and termed LESTR1 has recently been shown to function as a co-receptor (termed fusin) for lymphocyte-tropic HIV-1 strains2. Cells expressing CD4Expand
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DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-mycobacterialExpand
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Biology and pathogenesis of chikungunya virus
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a recent, unexpectedly severe epidemic in countries of the Indian Ocean region. Although many alphaviruses haveExpand
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Characterization of Reemerging Chikungunya Virus
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash,Expand
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Dendritic‐cell‐specific ICAM3‐grabbing non‐integrin is essential for the productive infection of human dendritic cells by mosquito‐cell‐derived dengue viruses
Dengue virus (DV) is a mosquito‐borne flavivirus that causes haemorrhagic fever in humans. DV primarily targets immature dendritic cells (DCs) after a bite by an infected mosquito vector. Here, weExpand
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HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication
Ligation of CCR5 by the CC chemokines RANTES, MIP-1α or MIP-1β, and of CXCR4 by the CXC chemokine SDF-1α, profoundly inhibits the replication of HIV strains that use these coreceptors for entry intoExpand
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