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A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
TLDR
A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
TLDR
It is demonstrated that SAMHD1 is an antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle, and is probably required for HIV-1 restriction.
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
TLDR
The identification of a human chemokine of the CXC type, stromal cell-derived factor 1 (SDF-1), as the natural ligand for LESTR/fusin, and the term CXCR-4 is proposed for this receptor, in keeping with the new Chemokine-receptor nomenclature.
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.
TLDR
Sera from individuals having received one dose of Pfizer or AstraZeneca vaccines barely inhibited variant Delta, and it was found that variant Delta spread is associated with an escape to antibodies targeting non-RBD and RBD Spike epitopes.
Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein
TLDR
It is shown that the expression of MHC–I at the surface of lymphoid, monocytic and epithelial cells was reduced in the presence of Nef protein from various HIV–1 strains, representing a previously undocumented viral mechanism for evading the immune response.
Biology and pathogenesis of chikungunya virus
TLDR
This Review highlights some of the most recent advances in understanding of the biology of CHIKV and its interactions with the host.
DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
TLDR
It is shown that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), which is likely to influence bacterial persistence and host immunity.
Characterization of Reemerging Chikungunya Virus
TLDR
The replication characteristics of recent clinical CHIKV strains are described, indicating that viral entry occurs through pH-dependent endocytosis and general insight is provided into the interaction between chikungunya virus and its mammalian host.
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
TLDR
The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains.
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
TLDR
The labelling of the two lower panels of Fig. 2b showed inhibition (left panel) or lack of inhibition (right panel) of syncytia formation by 100 nM SDF-1 or RANTES, respectively.
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