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Intravenous Iron Sucrose versus Oral Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients with Inflammatory Bowel Disease—A Randomized, Controlled, Open-Label, Multicenter
TLDR
Results suggest a better gastrointestinal tolerability for iron sucrose in short- and long-term efficacy as well as in tolerability over iron sulfate in the management of IDA in IBD. Expand
Short-chain fatty acid (SCFA) uptake into Caco-2 cells by a pH-dependent and carrier mediated transport mechanism
TLDR
The data suggest that the uptake of butyrate in Caco-2 cells occurs via a carrier mediated transport system specific for monocarboxylic acids, which is in accordance with characteristics of the MCT1. Expand
Prevalence of Anemia in Inflammatory Bowel Diseases in European Countries: A Systematic Review and Individual Patient Data Meta-analysis
TLDR
The overall prevalence of anemia in patients with Crohn's disease was 27% and 21% (95% confidence interval, 15–27) in Patients with ulcerative colitis, and 57% of the anemic patients were iron deficient. Expand
Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4.
TLDR
The data indicate that expression of functional BLT receptors may occur at the surface of endothelial cells in response to LPS, cytokines, and ligand, which in turn may have functional consequences during the early vascular responses to inflammation. Expand
Prospective evaluation of faecal neutrophil‐derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin
TLDR
This work has shown that the presence of neutrophil‐derived proteins in the blood stream is a markers of inflammatory bowel disease in patients with irritable bowel syndrome and these proteins have the potential to be a biomarker of inflammation. Expand
Combining infliximab with methotrexate for the induction and maintenance of remission in refractory Crohn's disease: a controlled pilot study
TLDR
The combination of infliximab with long-term methotrexate may be a promising concept in refractory Crohn's disease. Expand
Dominant Expression of the CysLT2 Receptor Accounts for Calcium Signaling by Cysteinyl Leukotrienes in Human Umbilical Vein Endothelial Cells
TLDR
HUVECs almost exclusively express the CysLT2R, a potent spasmogenic and proinflammatory agent with implications for ischemic heart disease and myocardial infarction, and signaling events involving Cys LT2R might trigger functional responses involved in the critical components of LT-dependant vascular reactions. Expand
Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells.
TLDR
The results clearly demonstrate that butyrate-mediated up-regulation of LL-37 is influenced by several signalling pathways and receptors including MAPKs as well as VDR and TGF-beta1, but not by PPARgamma. Expand
Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NF kappa B signalling.
TLDR
Findings provide evidence for the involvement of the nuclear hormone receptors PPAR gamma and VDR in butyrate-mediated inhibition of inducible NF kappa B activation dependent on the stimulated signalling pathway. Expand
Low Dose Methotrexate in Inflammatory Bowel Disease: Current Status and Future Directions
TLDR
It is concluded that low dose methotrexate is an effective and safe treatment in glucocorticoid-dependent and thiopurine intolerant patients with Crohn's disease but not ulcerative colitis. Expand
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