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Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
CD1d-restricted natural killer T (NKT) cells are innate-like lymphocytes that express a conserved T-cell receptor and contribute to host defence against various microbial pathogens. However, theirExpand
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Surface Proteins of Gram-Positive Bacteria and Mechanisms of Their Targeting to the Cell Wall Envelope
SUMMARY The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle that is assembled and turned over at designated sites. The cell wall also functions as a surfaceExpand
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Allelic replacement in Staphylococcus aureus with inducible counter-selection.
A method for rapid selection of allelic replacement mutations in the chromosome of Staphylococcus aureus is described. Plasmid pKOR1, an Escherichia coli/S. aureus shuttle vector, permits rapidExpand
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Assembly of pili on the surface of Corynebacterium diphtheriae
Pili of Gram‐negative pathogens are formed from pilin precursor molecules by non‐covalent association within the outer membrane envelope. Gram‐positive microbes employ the cell wall peptidoglycan asExpand
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Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands.
Strains of Staphylococcus aureus, an important human pathogen, display up to 20% variability in their genome sequence, and most sequence information is available for human clinical isolates that haveExpand
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Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria
SUMMARY The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only functions as a cytoskeletal element but also promotes interactions between bacteria and theirExpand
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Passage of Heme-Iron Across the Envelope of Staphylococcus aureus
The cell wall envelope of Gram-positive pathogens functions as a scaffold for the attachment of virulence factors and as a sieve that prevents diffusion of molecules. Here the isdgenesExpand
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An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis
Sortase (SrtA), an enzyme that anchors surface proteins to the cell wall of Gram-positive bacteria, cleaves sorting signals at the LPXTG motif. We have identified a second sortase (SrtB) in theExpand
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Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus
Lipoteichoic acid (LTA), a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. However, the molecular basis for its synthesis or function is not known. HereExpand
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Plague Bacteria Target Immune Cells During Infection
The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targetedExpand
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