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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Evidence is reported for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission, which provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures.
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
An atlas of genetic influences on osteoporosis in humans and mice
This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
- R. Karlsson Linnér, Pietro Biroli, Jonathan P. Beauchamp
- Biology, PsychologyNature Genetics
- 8 January 2019
A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.
Cell-cell interactions mediate the response of vascular smooth muscle cells to substrate stiffness.
A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
A genome-wide association study for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications and identifies genetic associations at two loci implicating the genes GDF15 and IGFBP7, providing insights into the genetic risk factors contributing to the disease.
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
A large GERD GWAS meta-analysis is conducted, identifying 25 independent genome-wide significant loci, many of which associate with BE and EA or with other traits such as BMI, and uncover potential new drug targets for these conditions.
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis