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Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.
The period when mice have elevated intraocular pressure extends from 6 months to 16 months, with 8-9 months representing an important transition to high IOP for many mice, and optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age. Expand
Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.
- S. John, R. S. Smith, +6 authors J. Heckenlively
- Investigative ophthalmology & visual science
- 1 May 1998
DBA/2J mice develop a progressive form of secondary angle-closure glaucoma that appears to be initiated by iris atrophy and the associated formation of synechias. Expand
Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development.
It is shown that Foxc1 (+/-)mice have anterior segment abnormalities similar to those reported in human patients, and IOP was normal in almost all mice analyzed, and may allow identification of genes that interact with Foxc 1 and Foxc2 to produce a phenotype with elevated IOP and glaucoma. Expand
Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage
The data support a role for optic nerve injury but not for NMDA receptor-mediated excitotoxicity in this glaucoma, and suggest that distinct somal and axonal degeneration pathways may need to be targeted to save vision. Expand
Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice
It is shown there are two chromosomal regions that contribute to the anterior segment changes and glaucoma and an earlier onset and more severe disease involving pigment dispersion and iris stromal atrophy is developed. Expand
Fish oil -- how does it reduce plasma triglycerides?
Reducing NEFA delivery to the liver would be a likely locus of action for fish oils (FO), as the key regulator of plasma NEFA is intracellular adipocyte lipolysis via hormone sensitive lipase (HSL), which increases as insulin sensitivity worsens. Expand
Intraocular pressure in genetically distinct mice: an update and strain survey
Genetically distinct mouse strains housed in the same environment have a broad range of intraocular pressure differences likely due to interstrain genetic differences that create a powerful resource for studying the regulation of IOP. Expand
Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function
- B. S. Kim, O. Savinova, +7 authors R. Johnson
- Biology, Medicine
- Molecular and Cellular Biology
- 15 November 2001
The generation and analysis of mice heterozygous and homozygous for a targeted null mutation in the trabecular meshwork inducible glucocorticoid response gene (TIGR), also known as the myocilin gene (MYOC), and in vivo findings demonstrate that Myoc mutant mice are both viable and fertile. Expand
Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis.
- D. Gould, J. Marchant, O. Savinova, Richard S. Smith, S. John
- Biology, Medicine
- Human molecular genetics
- 1 April 2007
It is shown that a mutation in the type IV collagen alpha 1 (Col4a1) gene can cause both ASD and optic nerve hypoplasia and a single dominant locus is identified that confers the phenotypic modification. Expand
Modification of Ocular Defects in Mouse Developmental Glaucoma Models by Tyrosinase
It is raised the possibility that a tyrosinase/l-dopa pathway modifies human PCG, which could open new therapeutic avenues, and Tyr modified the drainage structure dysgenesis in mice with a mutantFoxc1 gene, which is also involved in PCG. Expand