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Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes.
The potential of proniosomes as stable precursors for the immediate preparation of niosomal carrier systems is suggested. Expand
Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route.
The aim of this study was to investigate the influence of the nanocarrier surface charge on brain delivery of a model hydrophilic drug via the nasal route and the results revealed mild to moderate reversible inflammation of the nasal epithelium in rats treated with the anionic NLCs, and destruction of the lining mucosal nasal epithey in ratstreated with the cationic N LCs. Expand
Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion
The potential of experimental design in understanding the effect of the formulation variables on the quality of mouth dissolve tablets containing solid dispersion of a hydrophobic drug is demonstrated. Expand
Quality by design: understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function.
The potential of QBD is demonstrated in understanding the effect of the formulation variables on the quality of CyA self-nanoemulsified formulations by demonstrating the results that were remarkably close to the predicted values. Expand
Towards better modeling of chitosan nanoparticles production: screening different factors and comparing two experimental designs.
The aim of this study is to utilize statistical designs and mathematical modeling to end the continuous debate about the different variables that influence the production of nanoparticles using theExpand
Recent advances in topical formulation carriers of antifungal agents.
Fungal infections are amongst the most commonly encountered diseases affecting the skin. Treatment approaches include both topical and oral antifungal agents. The topical route is generally preferredExpand
Nebulizable colloidal nanoparticles co-encapsulating a COX-2 inhibitor and a herbal compound for treatment of lung cancer.
Biodistribution studies delineated the lung deposition potential of the nanoparticles accompanied with high distribution to the bones, brain and liver which are common metastatic sites of lung cancer, proving their promising nature in the treatment of Lung cancer. Expand
Formulation of anastrozole microparticles as biodegradable anticancer drug carriers
The results demonstrated that anastrozole microparticles with PLGA could be an alternative delivery method for the long-term treatment of breast cancer. Expand
Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy.
The confocal laser scanning microscopy has proven that the appendageal route is the main route of penetration of the prepared nanoparticles and has demonstrated the localization of the chitosan nanoparticles within the hair follicles from which the drug diffuses to deep layers of the skin and beyond. Expand
Determination of factors controlling the particle size and entrapment efficiency of noscapine in PEG/PLA nanoparticles using artificial neural networks
The ability of artificial neural networks to predict not only the particle size of the formed nanoparticles but also the drug entrapment efficiency may have a great impact on the design of polyethylene glycol and polylactide-based copolymers, and can be used to customize the required target formulations. Expand