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Doublecortin Is a Developmentally Regulated, Microtubule-Associated Protein Expressed in Migrating and Differentiating Neurons
Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed in the brainExpand
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LIS1, CLIP-170's Key to the Dynein/Dynactin Pathway
ABSTRACT CLIP-170 is a plus-end tracking protein which may act as an anticatastrophe factor. It has been proposed to mediate the association of dynein/dynactin to microtubule (MT) plus ends, and itExpand
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DCX, a new mediator of the JNK pathway
Mutations in the X‐linked gene DCX result in lissencephaly in males, and abnormal neuronal positioning in females, suggesting a role for this gene product during neuronal migration. In spite ofExpand
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Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats
LISSENCEPHALY (agyria-pachygyria) is a human brain malformation manifested by a smooth cerebral surface and abnormal neuronal migration1,2. Identification of the gene(s) involved in this disorderExpand
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Increased LIS1 expression affects human and mouse brain development
Deletions of the PAFAH1B1 gene (encoding LIS1) in 17p13.3 result in isolated lissencephaly sequence, and extended deletions including the YWHAE gene (encoding 14-3-3ε) cause Miller-Dieker syndrome.Expand
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Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.
Lissencephaly (agyria-pachygyria) is a human brain malformation manifested by a smooth cerebral surface and abnormal neuronal migration. Identification of the gene(s) involved in this disorder wouldExpand
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Doublecortin-like Kinase Controls Neurogenesis by Regulating Mitotic Spindles and M Phase Progression
The mechanisms controlling neurogenesis during brain development remain relatively unknown. Through a differential protein screen with developmental versus mature neural tissues, we identified aExpand
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The human glucocerebrosidase gene and pseudogene: structure and evolution.
We report the sequence of the entire human gene encoding beta-glucocerebrosidase and that of the associated pseudogene. The gene contains 11 exons extending from base pair 355 to base pair 7232 inExpand
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Alternative Splice Variants of Doublecortin-like Kinase Are Differentially Expressed and Have Different Kinase Activities*
Alternative splicing of mRNA transcripts expands the range of protein products from a single gene locus. Several splice variants of DCLK(doublecortin-like kinase) have previously been reported. Here,Expand
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The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC
Important clues to how the mammalian cerebral cortex develops are provided by the analysis of genetic diseases that cause cortical malformations [1-5]. People with Miller-Dieker syndrome (MDS) orExpand
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