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Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats
In recovered rats, re-transection of the cord above the primary transection site led to loss of recovery, indicating the involvement of long descending spinal tracts, and injection of macrophages into the site of injury is relatively non-invasive and, as the cells are autologous, it may be developed into a clinical therapy. Expand
Virtual monochromatic reconstruction of dual-energy unenhanced head CT at 65-75 keV maximizes image quality compared with conventional polychromatic CT.
Virtual monochromatic reconstruction of dual-energy unenhanced head CT scans at 65-75 keV (optimal energy levels) maximizes image quality compared with scans obtained with conventional polychromatic CT. Expand
Cranial CT with Adaptive Statistical Iterative Reconstruction: Improved Image Quality with Concomitant Radiation Dose Reduction
Evaluating the impact of an iterative-reconstruction algorithm, ASIR, on image-quality measures in reduced-dose head CT scans for adult patients showed that iterative reconstruction studies had lower image noise and increased low-contrast resolution while allowing lower radiation doses without affecting spatial resolution. Expand
The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach
The Massachusetts General Hospital Neuroradiology Division employed an experience and evidence based approach to develop a neuroimaging algorithm to best select patients with severe ischemic strokesExpand
Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.
Recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research are reviewed. Expand
Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction
A substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13–26 h following the onset of symptoms, and is proposed that this effect is consistent with a large drop in the intra‐axonal diffusivity. Expand
Restricted inflammatory reaction in the CNS: a key impediment to axonal regeneration?
It is suggested that restricted CNS recruitment and activation of macrophages are linked to regeneration failure and might reflect the immune privilege that characterizes the mammalian CNS. Expand
Accuracy of the Alberta Stroke Program Early CT Score during the First 3 Hours of Middle Cerebral Artery Stroke: Comparison of Noncontrast CT, CT Angiography Source Images, and CT Perfusion
In a retrospective cohort of MCA infarcts imaged <3 hours from stroke onset, ASPECTS was most accurately determined on CT perfusion CBV maps. Expand
The pathophysiology of lumbar puncture headache
The hypothesis that LPH is caused by an abnormal distribution of craniospinal elasticity is proposed, which is able to explain the orthostatic character of LPH, the fact that spinal but not cranial sites of leakage produce Orthostatic headache and the imperfect correlations both between recumbent CSF pressure and LPH and between reduced CSF volume and L PH. Expand
Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses.
The most common site of failure in patients treated with protons for medulloblastoma was outside of the posterior fossa, and development of techniques that do not require field matching may be of benefit. Expand