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Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial
The data suggest that the intra‐articular injection of ASCs is a safe therapeutic alternative to treat severe knee OA patients and a placebo‐controlled double‐blind phase IIb study is being initiated to assess clinical and structural efficacy.
Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head
This review summarizes recent experimental accomplishments and initial clinical findings in the field of regenerative medicine which apply cells, growth factors, and matrices to address the clinical problem of AVN.
MATN3 (matrilin-3) sequence variation (pT303M) is a risk factor for osteoarthritis of the CMC1 joint of the hand, but not for knee osteoarthritis
Osteoarthritis has a multifactorial aetilogy with a strong genetic component.1,2 Recently, Stefansson et al 3 identified a missense mutation (pT303M) in the MATN3 (matrilin-3) gene (designated as
Chondrocyte Differentiation in Human Osteoarthritis: Expression of Osteocalcin in Normal and Osteoarthritic Cartilage and Bone
Results clearly show that the expression of OC in chondrocytes correlates with chONDrocyte hypertrophy in OA, and it can be assumed that the altered microenvironment around osteoarthritic chondROcytes and systemic mediators could be potential inducers of this differentiation.
Hepatocyte growth factor in human osteoarthritic cartilage.
The results indicate that hepatocyte growth factor seems to be acting in an autocrine/paracrine manner in normal and osteoarthritic cartilage.
Course and prognosis of anti-basement membrane antibody (anti-BM-Ab)-mediated disease: report of 35 cases.
The earlier therapy starts, the better the result, and patients presenting early with a serum creatinine < 200 mumol/l and without severe glomerular alterations gained the most benefit from therapy, indicating that outcome may be improved by early diagnosis.
Matrilin-3 in human articular cartilage: increased expression in osteoarthritis.
The results indicate that matrilin-3 is a mandatory component of mature articular cartilage with its expression being restricted to chondrocytes from the tangential zone and the upper middle cartilage zone and a strong correlation was found between enhanced matril in-3 gene and protein expression and the extent of tissue damage.
Expression of type VI collagen in normal and osteoarthritic human cartilage.
It is demonstrated that in normal and osteoarthritic cartilage, type VI collagen is expressed in a zone specific pattern and suggests a potential role in the disease process.
Antineutrophil-cytoplasmic antibodies and antiglomerular basement membrane antibodies in Goodpasture's syndrome and in Wegener's granulomatosis.
The clinical prognosis of patients withAntiglomerular basement membrane (anti-GBM) diseases-including Goodpasture's (GP) syndrome-and Wegener's granulomatosis (WG) was similar to that of those patients who lacked these antibodies; in addition, the clinical prog outlook of these patients was similarTo that of the patients who lack these antibodies.