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- Publications
- Influence
Integrated genomic characterization of endometrial carcinoma
- D. Levine, Gad Stacey B. Kristian Eric Andrey Carrie Mike Cyriac Getz Gabriel Cibulskis Lander Sivachenko Sougnez L, +271 authors H. Sofia
- Biology, Medicine
- Nature
- 1 May 2013
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of… Expand
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
- D. Brat, Roel G. W. Verhaak, +304 authors J. Zhang
- Biology, Medicine
- The New England journal of medicine
- 25 June 2015
BACKGROUND
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that… Expand
Comprehensive molecular characterization of gastric adenocarcinoma
- A. Bass, V. Thorsson, +257 authors J. Liu
- Biology, Medicine
- Nature
- 23 July 2014
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a… Expand
The Immune Landscape of Cancer
- V. Thorsson, David L. Gibbs, +497 authors V. Jakrot
- Medicine, Biology
- Immunity
- 17 April 2018
SUMMARY We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six… Expand
Comprehensive genomic characterization of squamous cell lung cancers
- P. Hammerman, Doug Voet, +330 authors R. Shen
- Biology, Medicine
- Nature
- 6 September 2012
Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively… Expand
Genomic Classification of Cutaneous Melanoma
- Rehan Akbani, K. Akdemir, +349 authors L. Zou
- Biology, Medicine
- Cell
- 18 June 2015
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a… Expand
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
- D. Bulavin, Y. Higashimoto, +5 authors A. Fornace
- Biology, Medicine
- Nature
- 3 May 2001
Response to genotoxic stress can be considered as a multistage process involving initiation of cell-cycle arrest and maintenance of arrest during DNA repair. Although maintenance of G2/M checkpoints… Expand
Comprehensive molecular portraits of human breast tumors
- D. Koboldt, R. Fulton, +339 authors Jacqueline D. Palchik
- Biology, Medicine
- Nature
- 13 July 2012
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to… Expand
Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.
- Benjamin J. Raphael, R. Hruban, +263 authors J. Zenklusen
- Biology, Medicine
- Cancer cell
- 14 August 2017
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity.… Expand
The Jun Kinase/Stress-activated Protein Kinase Pathway Functions to Regulate DNA Repair and Inhibition of the Pathway Sensitizes Tumor Cells to Cisplatin*
- O. Potapova, A. Haghighi, +4 authors D. Mercola
- Biology, Medicine
- The Journal of Biological Chemistry
- 30 May 1997
We have studied the role of Jun/stress-activated protein kinase (JNK/SAPK) pathway in DNA repair and cisplatin resistance in T98G glioblastoma cells. JUN/SAPK is activated by DNA damage and… Expand
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