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Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, pore-formingExpand
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Molecular basis of functional diversity of voltage‐gated potassium channels in mammalian brain.
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization ofExpand
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hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large‐conductance calcium‐activated potassium channel β subunit family
We cloned two β subunits of large‐conductance calcium‐activated potassium (BK) channels, hKCNMB3 (BKβ1) and hKCNMB4 (BKβ4). Profiling mRNA expression showed that hKCNMB3 expression is enriched inExpand
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Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
In humans, mutations in the KCNQ2 or KCNQ3 potassium-channel genes are associated with an inherited epilepsy syndrome. We have studied the contribution of KCNQ/M-channels to the control of neuronalExpand
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Ancillary subunits associated with voltage-dependent K+ channels.
Since the first discovery of Kvbeta-subunits more than 15 years ago, many more ancillary Kv channel subunits were characterized, for example, KChIPs, KCNEs, and BKbeta-subunits. The ancillaryExpand
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Presynaptic Ca2+-Activated K+ Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release
Large-conductance Ca2+-activated K+ channels (BK, also called Maxi-K orSlo channels) are widespread in the vertebrate nervous system, but their functional roles in synaptic transmission in theExpand
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Conserved Kv4 N-terminal Domain Critical for Effects of Kv Channel-interacting Protein 2.2 on Channel Expression and Gating*
Association of Kv channel-interacting proteins (KChIPs) with Kv4 channels leads to modulation of these A-type potassium channels (An, W. F., Bowlby, M. R., Betty, M., Cao, J., Ling, H. P., Mendoza,Expand
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Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I.
Progressive familial heart block type I (PFHBI) is a progressive cardiac bundle branch disease in the His-Purkinje system that exhibits autosomal-dominant inheritance. In 3 branches of a large SouthExpand
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Immunohistochemical Localization of Five Members of the KV1 Channel Subunits: Contrasting Subcellular Locations and Neuron‐specific Co‐localizations in Rat Brain
A large variety of potassium channels is involved in regulating integration and transmission of electrical signals in the nervous system. Different types of neurons, therefore, require specificExpand
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Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals
Tissue expression and distribution of the high-conductance Ca(2+)- activated K+ channel Slo was investigated in rat brain by immunocytochemistry, in situ hybridization, and radioligand binding usingExpand
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