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High-throughput microfluidic single-cell RT-qPCR
A long-sought milestone in microfluidics research has been the development of integrated technology for scalable analysis of transcription in single cells. Here we present a fully integratedExpand
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In-depth characterization of the microRNA transcriptome in a leukemia progression model.
MicroRNAs (miRNAs) have been shown to play important roles in physiological as well as multiple malignant processes, including acute myeloid leukemia (AML). In an effort to gain further insight intoExpand
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MicroRNA-146a disrupts hematopoietic differentiation and survival.
OBJECTIVE MicroRNAs (miRNAs) are short noncoding RNAs capable of exerting dramatic effects by postranscriptionally regulating numerous messenger RNA targets. Toll-like receptor-4 (TLR-4) activationExpand
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Comprehensive microRNA expression profiling of the hematopoietic hierarchy
The hematopoietic system produces a large number of highly specialized cell types that are derived through a hierarchical differentiation process from a common stem cell population. miRNAs areExpand
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MiR-139-5p is a potent tumor suppressor in adult acute myeloid leukemia
Hematopoiesis depends on a tightly controlled balance of selfrenewal, proliferation, cell death and differentiation. Although the disturbance of this equilibrium creates a predisposition toExpand
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Purification and quantitation of bacteriophage M13 using desalting spin columns and digital PCR.
Separation of small molecules such as biotinylated baits from solutions of filamentous bacteriophage is achieved generally through polyethylene glycol precipitation of the phage and centrifugationExpand
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Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia
Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to theExpand
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Probing the complexity of miRNA expression across hematopoiesis
Comment on: Petriv OI, et al. Proc Natl Acad Sci USA 2010; 107:15443-8.
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Identification of New microRNA Biomarkers and Candidate Target Genes in Primitive CML Cells Using Global Comparative RNA analyses
Imatinib mesylate (IM) and other ABL tyrosine kinase inhibitors (TKIs) have had a major impact on early phase CML patient outcomes. However, they are rarely curative and initial and acquired TKIExpand
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Methods for Multiplex Template Sampling in Digital PCR Assays
The efficient use of digital PCR (dPCR) for precision copy number analysis requires high concentrations of target molecules that may be difficult or impossible to obtain from clinical samples. ToExpand
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