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In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species
Piperlonguminine did not show any significant in vitro cytotoxic effect at experimental exposure levels, but showed an in vivo antitumor effect, reinforcing the anticancer potential of spice components. Expand
Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice.
In the present work, we studied the effects of piplartine (PIP), an amide alkaloid isolated from the roots of Piper tuberculatum (Piperaceae), in the elevated plus maze, open field, rota rod,Expand
Chemical composition and larvicidal activity of the essential oils of Cordia leucomalloides and Cordia curassavica from the Northeast of Brazil
Os resultados mostraram that ambos os oleos apresentaram atividade biologica significativa, particularmente o oleo essencial de C. leucomalloides, o qual foi capaz of matar 98,7% das larvas numa concentracao de 100 ppm. Expand
Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice.
Topically applied physalin E inhibited the TPA and oxazolone-induced dermatitis, leading to substantial reductions in ear edema/thickness, pro-inflammatory cytokines, and MPO activity. Expand
Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole
Ascaridole has an interesting antitumor activity in sarcoma 180 murine model, probably related to the described cytotoxic activity, and, moreover, its presence in the essential oil from the leaves of C. regelianus could explain, at least in part, the ethnopharmacological use of this plant in the treatment of cancer. Expand
Chemical composition and larvicidal activity of the essential oils from Eupatorium betonicaeforme (D.C.) Baker (Asteraceae).
The results obtained show that the essential oil from roots and 2,2-dimethyl-6-vinylchroman-4-one could be considered as natural larvicidal agents against Aedes aegypti larvae survival. Expand
Pyrrolizidine alkaloids from Heliotropium indicum
Helindicine (1), a new pyrrolizidine alkaloid with unusual structural features, together with the known lycopsamine (2), were isolated from the roots of Heliotropium indicum (Boraginaceae). TheExpand
Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet.
It is suggested that BA has an antiobese potential through modulation of fat and carbohydrate metabolism, and it may be a suitable lead compound in the treatment of obesity. Expand
In‐vitro and in‐vivo antitumour activity of physalins B and D from Physalis angulata
These compounds were probably responsible for the previously described antitumour activity of ethanol extracts of P. angulata, and their identification and characterization presented here could explain the ethnopharmacological use of this species in the treatment of cancer. Expand
Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.
Results show that quinone fraction isolated from the heartwood of Auxemma oncocalyx Taub significantly inhibited paw edema induced by carrageenan at the second, third, and fourth hours, and QF was less effective orally. Expand