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Synthesis and application of a new isothiocyanate as a chiral derivatizing agent for the indirect resolution of chiral amino alcohols and amines
Abstract The synthesis of the optical pure trans -1,2-diaminocyclohexane (DACH)-based N-3,5-dinitrobenzoyl-DACH-isothiocyanate (DDITC) is straightforward and the compounds, available in R , R and S ,Expand
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Synthesis of new stable aliphatic isothiocyanate-based chiral derivatizing agent and application to indirect separation of chiral amino and thiol compounds
SummaryA new chiral derivatizing agent (CDA) (1S, 2S) N-[(2-isothiocyanato)-cyclohexyl)-pivalinoyl amide ((S,S)-PDITC) is described. The CDA is available from 1,2-diamino cyclohexane (DACH) via aExpand
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Separation of enantiomers of 4-aryldihydropyrimidines by direct enantioselective HPLC. A critical comparison of chiral stationary phases
Abstract The separation of the enantiomers of 29 racemic 4-aryldihydropyrimidine-5-carboxylates (DHPMs), aza-analogs of nifedipine-type dihydropyridine calcium channel modulators, was evaluated inExpand
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Indirect separation of chiral proteinogenic α-amino acids using the fluorescence active (1R,2R)-N-[(2-isothiocyanato)cyclohexyl]-6-methoxy-4-quinolinylamide) as chiral derivatizing agent: A comparison
Abstract Enantiomerically pure trans-1,2-diaminocyclohexane (DACH) based (1R,2R)- and (1S,2S)-N-[(2-isothiocyanato)cyclohexyl]-6-methoxy-4-quinolinylamide ((R,R)- and (S,S)-CDITC) was designed as aExpand
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The chemical and thermal stability of the acetamido group of (R)‐ and (S)‐atenolol: Synthetic and chromatographic studies
The chemical stability of the acetamido moiety of the β-blocker atenolol toward possible dehydration causing a nitrile formation during an acid-catalyzed chiral derivatization procedure withExpand
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Diphenylethanediamine (DPEDA) derivatives as chiral selectors: IV. A comparison of 3,5-dinitrobenzoylated (S,S)- and (S,R)-DPEDA-derived chiral stationary phases with Pirkle's standard
Undecanoyl bound 3,5-dinitrobenzoyl-(S,R)-1,2-diphenylethane-1,2-diamine as chiral selector has been synthesized and used as a chiral stationary phase for normal phase HPLC. It is compared with theExpand
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