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Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.
TLDR
It is indicated that the expression of telomerase induces immortalization of normal human esophageal keratinocytes without inactivation of p16INK4a/pRb pathway or abrogation of the p53 pathway.
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Cell cycle dysregulation in oral cancer.
TLDR
The molecular alterations and understanding the functional consequences of the dysregulation of the cell cycle apparatus in the malignant oral keratinocyte will uncover novel diagnostic and therapeutic approaches.
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Outpatient chemotherapy with gemcitabine and oxaliplatin in patients with biliary tract cancer
TLDR
The GEMOX-3 protocol is active and well tolerated in patients with advanced BTC and can be applied in an outpatient setting with three visits per month only.
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A mouse model of human oral-esophageal cancer.
TLDR
It is demonstrated that L2D1(+)/p53(+/-) mice provide a well-defined, novel, and faithful model of oral-esophageal cancer, which allows for the testing of novel chemopreventive, diagnostic, and therapeutic approaches.
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Effect of vardenafil, an inhibitor of phosphodiesterase‐5, on portal haemodynamics in normal and cirrhotic liver – results of a pilot study
Background  Dysregulation of the cyclic guanosine 3′,5′ monophosphate–nitric oxide system is in part responsible for portal hypertension in cirrhosis.
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Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver
TLDR
The results suggest that promoter methylation of tumor‐associated genes is a common event in hepatocarcinogenesis and quantitative analyses of methylated GSTP1 and p16INK4a promoter may serve as a powerful molecular marker in detecting HCC in biopsies.
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Cytokine gene expression in immune mice reinfected with Mycoplasma pneumoniae: the role of T cell subsets in aggravating the inflammatory response.
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Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction
TLDR
In human esophageal keratinocytes, it was found that Ha-RasG12V induced senescence regardless of p53 status and telomerase activation, suggesting that Ras-mediated senescences may involve distinct mechanisms between human and mouse cells.
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Prognostic Relevance of Carbohydrate Antigen 19-9 Levels in Patients with Advanced Biliary Tract Cancer
TLDR
The results indicate that pretreatment CA 19-9 levels and CA19-9 decrease after chemotherapy are of prognostic relevance in patients with BTC.
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Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism.
TLDR
It is demonstrated that immortalization of oral keratinocytes can be independent of telomerase activation, involving an alternative pathway of telomere maintenance (ALT), as well as cyclin D1 overexpression and p53 inactivation.
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